Active Pharmaceutical Ingredients

Catalog ID80071728

CAS NO.153559-49-0

Purity 96%

MDL NumberMFCD00932428

Molecular Formula C24H28O2

Molecular Weight 348.483

Melting point: 220-225°C

Item	Information
Mechanism of Action	Bexarotene is a selective retinoid X receptor (RXR) agonist. It regulates gene expression involved in cell differentiation, proliferation, and apoptosis, thus inhibiting cancer cell growth.
Therapeutic Uses	Primarily used to treat cutaneous T-cell lymphoma (CTCL) in patients who have not responded to other treatments. It is also under investigation for other cancers.
Formulations	Available as capsules (75 mg) and topical gel.
Dosage	The recommended oral dose is 300 mg/m² daily, which can be adjusted based on patient response and tolerance.
Side Effects	Common side effects include hyperlipidemia, headache, dry skin, and photosensitivity. Severe adverse events may include hepatotoxicity, pancreatitis, and teratogenic effects.
Drug Interactions	Bexarotene is metabolized by CYP3A4; thus, inhibitors of this enzyme (e.g., ketoconazole, clarithromycin) can increase plasma levels of bexarotene and should be avoided.
Storage Conditions	Store powder at -20°C for 3 years; in solvent at -80°C for 1 year.
Approval and Brand Name	Approved by the FDA in 1999. Marketed under the brand name Targretin.

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