Active Pharmaceutical Ingredients

Catalog ID80017206

CAS NO.5579-84-0

Purity 98%

MDL NumberMFCD00012813

EINEC226-966-5

Molecular formula C8H12N2.2HCl

Molecular weight 209.1162

Melting point: 150~154°C

Aspect	Details
Chemical Properties	– Molecular Formula: C8H14Cl2N2<br>- Molecular Weight: 209.11 g/mol<br>- CAS Number: 5579-84-0<br>- Physical Appearance: White to almost white solid
Mechanism of Action	– Betahistine is a histamine analog and a weak H1 receptor agonist and potent H3 receptor antagonist.<br>- It acts as a vasodilator, reducing endolymphatic pressure in the inner ear, which helps to alleviate symptoms of Ménière’s disease.
Indications	– Treatment of Ménière’s disease (vertigo, tinnitus, hearing loss, nausea).<br>- Used in the treatment of acute and chronic ischemic cerebrovascular diseases.<br>- Also used for vascular headaches and other conditions where vasodilation is beneficial.
Pharmacokinetics	– Absorption: Rapid and complete after oral administration.<br>- Distribution: Widely distributed in tissues, with high concentration in the liver.<br>- Metabolism: Metabolized in the liver to inactive metabolites.<br>- Excretion: Primarily excreted in urine within 3 days.<br>- Half-Life: Approximately 3.5 hours.
Dosage Forms	– Oral tablets.<br>- Oral liquid.<br>- Injection solutions.
Administration	– Oral: Typically taken 3 times daily, with doses ranging from 4-8 mg per dose.<br>- Injection: Intramuscular or intravenous administration, with doses ranging from 10-30 mg per day.
Adverse Effects	– Common: Headache, nausea, indigestion.<br>- Less common: Dizziness, gastrointestinal disturbances.
Contraindications	– Hypersensitivity to betahistine or any of its components.<br>- Caution in patients with peptic ulcers or bronchial asthma.
Special Considerations	– Use with caution in patients with cardiovascular diseases, liver diseases, or during pregnancy and breastfeeding.<br>- Monitor for signs of gastrointestinal bleeding or worsening of asthma symptoms.
Storage Conditions	Store in a cool, dry place, protected from light and moisture

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