Betahistine dihydrochloride CAS NO.5579-84-0
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017206
CAS NO.5579-84-0
Purity 98%
MDL NumberMFCD00012813
EINEC226-966-5
Molecular formula C8H12N2.2HCl
Molecular weight 209.1162
Melting point: 150~154°C
| Aspect | Details |
|---|---|
| Chemical Properties | – Molecular Formula: C8H14Cl2N2<br>- Molecular Weight: 209.11 g/mol<br>- CAS Number: 5579-84-0<br>- Physical Appearance: White to almost white solid |
| Mechanism of Action | – Betahistine is a histamine analog and a weak H1 receptor agonist and potent H3 receptor antagonist.<br>- It acts as a vasodilator, reducing endolymphatic pressure in the inner ear, which helps to alleviate symptoms of Ménière’s disease. |
| Indications | – Treatment of Ménière’s disease (vertigo, tinnitus, hearing loss, nausea).<br>- Used in the treatment of acute and chronic ischemic cerebrovascular diseases.<br>- Also used for vascular headaches and other conditions where vasodilation is beneficial. |
| Pharmacokinetics | – Absorption: Rapid and complete after oral administration.<br>- Distribution: Widely distributed in tissues, with high concentration in the liver.<br>- Metabolism: Metabolized in the liver to inactive metabolites.<br>- Excretion: Primarily excreted in urine within 3 days.<br>- Half-Life: Approximately 3.5 hours. |
| Dosage Forms | – Oral tablets.<br>- Oral liquid.<br>- Injection solutions. |
| Administration | – Oral: Typically taken 3 times daily, with doses ranging from 4-8 mg per dose.<br>- Injection: Intramuscular or intravenous administration, with doses ranging from 10-30 mg per day. |
| Adverse Effects | – Common: Headache, nausea, indigestion.<br>- Less common: Dizziness, gastrointestinal disturbances. |
| Contraindications | – Hypersensitivity to betahistine or any of its components.<br>- Caution in patients with peptic ulcers or bronchial asthma. |
| Special Considerations | – Use with caution in patients with cardiovascular diseases, liver diseases, or during pregnancy and breastfeeding.<br>- Monitor for signs of gastrointestinal bleeding or worsening of asthma symptoms. |
| Storage Conditions | Store in a cool, dry place, protected from light and moisture |
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