Benztropine mesylate
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80071727
CAS NO.132-17-2
Purity 98%
MDL NumberMFCD00074784
EINEC205-048-8
Molecular FormulaC21H25NO.CH4O3S
Molecular Weight403.535
Melting point: 133~135℃
| Item | Information |
|---|---|
| Mechanism of Action | Benztropine mesylate antagonizes acetylcholine and histamine receptors. It blocks muscarinic receptors in the central nervous system and smooth muscles, reducing cholinergic effects and alleviating Parkinson’s disease symptoms. |
| Therapeutic Uses | FDA-approved for adjunctive therapy in all forms of parkinsonism and for managing drug-induced extrapyramidal symptoms (EPS) and acute dystonic reactions. It is also used off-label for chronic sialorrhea and intractable hiccups. |
| Formulations | Available as tablets (0.5 mg, 1 mg, 2 mg) for oral use, and as an injection (1 mg/mL) for intramuscular (IM) or intravenous (IV) administration. |
| Dosage | For parkinsonism, the usual daily dose is 1 mg to 2 mg, with a range of 0.5 mg to 6 mg. For drug-induced EPS, 1 mg to 4 mg once or twice daily is recommended. |
| Side Effects | Common side effects include dry mouth, blurred vision, constipation, nausea, and confusion. Severe side effects may include allergic reactions, hallucinations, and paralytic ileus. |
| Drug Interactions | Caution is advised with concomitant use of antipsychotic drugs (e.g., phenothiazines, haloperidol) and tricyclic antidepressants due to potential additive anticholinergic effects. |
| Contraindications | Contraindicated in children under three years of age due to atropine-like side effects. |
| Special Populations | Use with caution in patients with hepatic or renal impairment, as specific data are lacking. For breastfeeding and pregnancy, data are limited, and caution is advised. |
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