Benzimidazole
Agrochemicals 2025-03-02
Benzimidazole (CAS No. 51-17-2)
1. Basic Information
- IUPAC Name: 1H-Benzimidazole
- Synonyms:
- Benziminazole
- Azindole
- CAS Number: 51-17-2
- Molecular Formula: C₇H₆N₂
- Molecular Weight: 118.14 g/mol
- Appearance: White to off-white crystalline powder
- Odor: Slight aromatic odor
2. Physical and Chemical Properties
| Property | Value |
|---|---|
| Melting Point | 170–172°C (338–342°F) |
| Boiling Point | >360°C (dec.) |
| Density | 1.24 g/cm³ (20°C) |
| Solubility | – Water: Slightly soluble (1.7 g/L at 25°C) |
| – Organic solvents: Soluble in ethanol, methanol, DMSO | |
| pKa | 5.53 (basic), 12.8 (acidic) |
| Refractive Index | 1.600 (20°C) |
3. Chemical Structure
N
// \\
C C
| |
C---N
\\ //
C=C
(Fused benzene and imidazole rings)
4. Hazards (GHS Classification)
- Health Hazards:
- Harmful if swallowed (H302)
- Causes skin irritation (H315)
- Causes serious eye irritation (H319)
- Environmental: Not classified
- NFPA Rating: Health 2, Flammability 1, Reactivity 0
5. Storage and Handling
- Storage:
- Keep in tightly sealed containers
- Store in a cool, dry, well-ventilated area
- Handling:
- Use nitrile gloves and safety goggles
- Avoid dust formation
6. Applications
- Pharmaceuticals:
- Core structure for anthelmintics (e.g., albendazole)
- Antifungal and antiviral agents
- Agrochemicals:
- Fungicides (e.g., carbendazim)
- Industrial Uses:
- Corrosion inhibitor
- Polymer stabilizer
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