Active Pharmaceutical Ingredients

Catalog ID80017970

CAS NO.5003-48-5

Purity 98%

MDL NumberMFCD00864257

Molecular Formula C17H15NO5

Molecular Weight 313.3047

Melting point: 175~181°C

Category	Details
Chemical Properties	Molecular formula: C16H15NO4<br> Molecular weight: 285.30 g/mol<br> Chemical name: 2-Acetoxybenzoic acid p-acetamidophenyl ester
Physical Properties	Appearance: White crystalline powder
Mechanism of Action	Benorilate is a prodrug that releases both aspirin and paracetamol (acetaminophen) upon metabolism. Aspirin inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and providing anti-inflammatory, analgesic, and antipyretic effects. Paracetamol acts centrally to reduce pain and fever.
Therapeutic Uses	Indications: Used for mild to moderate pain, such as headaches, toothaches, menstrual pain, and musculoskeletal pain.<br> Fever Reduction: Effective in reducing fever.<br> Inflammation: Provides anti-inflammatory effects for conditions like arthritis.
Dosage	Adults: 0.5–1.0 g orally, 3–4 times daily.<br> Elderly: Maximum daily dose of 2.6 g.
Side Effects	Gastrointestinal disturbances, hypersensitivity reactions, tinnitus, heartburn, drowsiness, dizziness.
Contraindications	Aspirin Sensitivity: Not suitable for individuals allergic to aspirin.<br> Bleeding Disorders: Avoid in patients with bleeding disorders.<br> Peptic Ulcer Disease: Contraindicated in patients with active peptic ulcers.<br> Severe Liver or Kidney Impairment: Use with caution in severe liver or kidney impairment.
Storage Conditions	Store in a cool, dry place, protect from light and moisture

 Names and Identifiers

Name	benorilate
Synonyms	benoral benortan benorilate Benorylate benorilato fenasparate aspirinacetaminophenester p-acetamidophenylacetylsalicylate 4-acetamidophenyl O-acetylsalicylate 4′-(acetamido)phenyl-2-acetoxybenzoate 2-acetoxy-4′-(acetamino)phenylbenzoate 4-(acetylamino)phenyl 2-(acetyloxy)benzoate
CAS	5003-48-5
EINECS	225-674-5
InChI	InChI=1/C17H15NO5/c1-11(19)18-13-7-9-14(10-8-13)23-17(21)15-5-3-4-6-16(15)22-12(2)20/h3-10H,1-2H3,(H,18,19)

5003-48-5 – Physico-chemical Properties

Molecular Formula	C17H15NO5
Molar Mass	313.3
Density	1.2016 (rough estimate)
Melting Point	177-181℃
Boling Point	453.11°C (rough estimate)
Flash Point	279°C
Water Solubility	20mg/L(21 ºC)
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	1.23E-11mmHg at 25°C
Appearance	Solid
Color	White
Merck	14,1045
pKa	14.17±0.70(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.4500 (estimate)
Physical and Chemical Properties	White crystalline powder. Melting Point 175-176 °c. Soluble in hot alcohol, insoluble in water.
Use	Esterification of acetaminophen and aspirin, suitable for rheumatoid arthritis, rheumatoid arthritis, Head Pain, neuralgia, fever, etc

5003-48-5 – Risk and Safety

RTECS	VO0720000
Toxicity	LD50 in mice, rats (mg/ml): 2000, ~10000 orally; 1255, 1830 i.p. (Robertson)

Reference Information

Pharmacological action and mechanism of action	Benorilate is a neutral compound that binds aspirin and acetaminophen with ester bonds. It has antipyretic and analgesic effects, and has less adverse reactions than aspirin. Patients are easy to tolerate. After oral administration, it is not hydrolyzed in the gastrointestinal tract, absorbed in the intestine and quickly reaches an effective concentration in the blood. The characteristic is that it rarely causes gastrointestinal bleeding.
adverse reactions	1. mild gastrointestinal reactions such as vomiting, constipation, heartburn, etc. have also been reported to cause diarrhea. 2. It can cause rash. 3. still visible drowsiness, dizziness, disorientation and other neurological and mental symptoms.
use	this product is the esterification product of aspirin and paracetamol, and is a new anti-inflammatory, antipyretic, analgesic and rheumatic drug. Adverse reactions are smaller than aspirin, and patients are easy to tolerate. After oral administration, it is not hydrolyzed in the gastrointestinal tract, is easily absorbed and quickly reaches an effective concentration in the blood. Mainly used for rheumatoid arthritis, acute and chronic rheumatoid arthritis, rheumatic pain, cold and fever, headache, postoperative pain, neuralgia, etc. Adverse reactions include vomiting, dyspepsia and constipation. Sleepiness, dizziness and disorientation can still be seen. When the dosage is too large, most people may have tinnitus and deafness. Use with caution in patients with liver and kidney function impairment. Aspirin allergy is contraindicated. The oral LD50 was 2000mg/kg for mice and -10000mg/kg for rats. The LD50 was 1255mg/kg for mice and 1830mg/kg for rats. The esterification of acetaminophen and aspirin, suitable for rheumatoid arthritis, rheumatoid arthritis, headache, neuralgia, fever, etc.
Production method	Acetylsalicylic acid is acyl chlorinated to generate acetylsalicylchloride, which is then condensed with p-acetamido phenol to obtain benorilate.

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