Active Pharmaceutical Ingredients

English Synonyms 2-Cyano-3,12-dioxooleana-1,9-dien-28-oic acid (4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-Cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylic acid

Catalog ID101121

CAS NO.218600-44-3 Purity 95%

MDL NumberMFCD07772296

EINEC Molecular Formula C31H41NO4

Molecular Weight 491.668

Category	Content
Generic Name	Bardoxolone
Chemical Formula	C31H41NO4
Mechanism of Action	Bardoxolone is a synthetic triterpenoid that strongly activates the Keap1/Nrf2 system. It covalently binds to Keap1, releasing Nrf2 into the nucleus to induce transcription of antioxidant and anti-inflammatory genes. This reduces oxidative stress and inflammation.
Indications	Investigated for the treatment of chronic kidney disease (CKD), including diabetic kidney disease (DKD) and Alport syndrome.
Clinical Status	Currently in Phase 3 clinical trials for Alport syndrome and ADPKD.
Developer	Reata Pharmaceuticals
Potential Benefits	Bardoxolone methyl has shown promise in improving glomerular filtration rate (GFR) and delaying disease progression in CKD.
Other Properties	Bardoxolone methyl is a first-in-class antioxidant inflammation modulator that does not affect systemic hemodynamics

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