Atomoxetine HCl
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80019531
CAS NO.82248-59-7
Purity 99%
MDL NumberMFCD06410992
Molecular FormulaC17H21NO.HCl
Molecular Weight291.8157
Melting point: 166~172°C
| Category | Information |
|---|---|
| Chemical Properties | – Molecular Formula: C₁₇H₂₂ClNO<br>- Molecular Weight: 291.82 g/mol |
| Mechanism of Action | – Selective norepinephrine reuptake inhibitor (SNRI) with a Ki value of 5 nM for the norepinephrine transporter.<br>- Has weaker affinity for the serotonin transporter (Ki = 77 nM) and dopamine transporter (Ki = 1451 nM). |
| Clinical Uses | – FDA-approved for the treatment of Attention-Deficit/Hyperactivity Disorder (ADHD) in pediatric and adult patients.<br>- Investigated for improving executive function and attention in patients with PTSD. |
| Pharmacokinetics | – Absorption: Rapidly absorbed with peak plasma concentrations reached within 1-2 hours.<br>- Distribution: High plasma protein binding.<br>- Metabolism: Metabolized by CYP2D6.<br>- Elimination: Half-life of approximately 5 hours. |
| Adverse Effects | – Common side effects include headache, nausea, insomnia, and dry mouth.<br>- May cause increases in blood pressure and heart rate. |
| Storage Conditions | – Store at -20°C for up to 3 years (powder); in solvent at -80°C for up to 1 year. |
| Synonyms | – Strattera.<br>- LY 139603.<br>- Tomoxetine Hydrochloride. |
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