Androsta-1,4-diene-3,17-dione
Pharmaceutical Materials 2025-03-02
CAS Number: 897-06-3
Molecular Formula: C19H24O2
Molecular Weight: 284.39 g/mol
Appearance: White crystalline powder
Melting Point: 138-139 °C
Boiling Point: 434.2 °C
Usage: Used as an intermediate in steroid hormone synthesis.
| Aspect | Details |
|---|---|
| Name | Androsta-1.4-diene-3.17-dione |
| Synonyms | 1.4-Androstadiene-3.17-dione; Androstadienedione; ADD |
| CAS Number | 897-06-3 |
| Chemical Formula | C₁₉H₂₄O₂ |
| Molecular Weight | 284.39 g/mol |
| Physical Properties | – Appearance: White to pale yellow crystalline solid |
| – Melting Point: 138–139°C | |
| – Solubility: Soluble in organic solvents (e.g., methanol, chloroform); insoluble in water | |
| Stability | Sensitive to oxidation; requires storage in airtight containers under inert gas to prevent degradation |
| Synthetic Route | – Microbial Conversion: Derived from 4-androstene-3.17-dione (4-AD) via enzymatic dehydrogenation (e.g., using Nocardia spp.) |
| – Chemical Synthesis: From cholesterol or plant sterols through a series of reactions including dehydrogenation and cyclization | |
| Applications | – Pharmaceuticals: Intermediate for corticosteroids (e.g., prednisolone, dexamethasone) and oral contraceptives |
| – Research: Model compound for studying steroid biosynthesis pathways | |
| Safety Precautions | Handle under inert atmosphere; wear PPE; avoid prolonged exposure to air/light |
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