Amorolfine hydrochloride CAS No.:78613-38-4
Pharmaceutical Materials 2025-03-03
Amorolfine hydrochloride (CAS No.: 78613-38-4), a morpholine antifungal agent, is a key therapeutic for treating onychomycosis and dermatophytosis. As a prodrug, it inhibits fungal ergosterol biosynthesis by targeting Δ14-reductase and Δ7-Δ8-isomerase, disrupting cell membrane integrity. Marketed under brands like Loceryl® and Curanail®, it forms a water-resistant film on nails, ensuring sustained drug release for up to 7 days. Pharmacokinetic studies reveal low systemic absorption (≤0.1%), with minimal adverse effects. The compound’s mechanism involves dual activity—fungistatic at lower concentrations and fungicidal at higher doses, making it effective against dermatophytes (e.g., Trichophyton), yeasts, and some molds. Its synthesis employs Claisen-Schmidt condensation and catalytic hydrogenation, yielding a white crystalline powder with high purity (≥99%).
Usage:Used as antifungal agent.
Packaging and Shipping： 25kg/drum or as per buyer’s requirements.
Storage: Storage in ventilated low temperature dry warehouse;Keep container closed and separately from open flame and heat source.
| Name | Amorolfine Hydrochloride |
| Synonyms | AMOROLFINE HCL Amorolfine HCI Amorolfine hydrochloride Amorolfine Hydrochloride (2R,6S)-2,6-dimethyl-4-{2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl}morpholine Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, cis- Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, hydrochloride, (2R,6S)-rel- |
| CAS | 78613-38-4 106614-68-0 |
| Molecular Formula | C21H36ClNO |
| Molar Mass | 353.97 |
| Density | 0.924g/cm3 |
| Melting Point | 204-208℃ |
| Boling Point | 407.1°C at 760 mmHg |
| Flash Point | 119.6°C |
| Solubility | Soluble in DMSO (≥5 mg/ml,warmed), water (9l mg/ml), and ethanol (71 mg/ml). |
| Vapor Presure | 7.75E-07mmHg at 25°C |
| Storage Condition | 2-8℃ |
| Refractive Index | 1.488 |
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