Amorolfine HCl
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID80017974
CAS NO.78613-38-4
Purity 98%
MDL NumberMFCD00903738
Molecular FormulaC21H35ON.HCl
Molecular Weight353.9696
Melting point: 204~206°C
| Category | Details |
|---|---|
| Chemical Properties | Molecular formula: C21H36ClNO<br> Molecular weight: 353.97 g/mol |
| Physical Properties | Appearance: White to off-white crystalline powder<br> Melting point: 142–145°C<br> Solubility: Freely soluble in ethanol, slightly soluble in water |
| Mechanism of Action | Inhibits ergosterol biosynthesis by blocking Δ14-reductase and Δ7,8-isomerase, leading to depletion of ergosterol and accumulation of ignosterol in fungal cell membranes. |
| Therapeutic Uses | Antifungal Agent: Effective against dermatophytes, yeasts, and other fungi. Used topically for treating onychomycosis (fungal nail infections) and other skin fungal infections. |
| Formulations | Available as nail lacquer (5% concentration) and dermatological creams. |
| Storage Conditions | Store in airtight containers below 25°C, protect from moisture. |
| Safety Information | Side Effects: May cause local irritation or allergic reactions.<br> Contraindications: Avoid in patients with hypersensitivity to amorolfine. |
| Brand Names | Loceryl, Locetar, Curanail, Odenil |
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