Aminoguanidine hydrochloride
Active Pharmaceutical Ingredients 2025-03-03
Catalog ID811963
CAS NO.1937-19-5
Purity 98%
MDL NumberMFCD00039074
EINEC217-707-7
Molecular FormulaCH6N4.HCl
Molecular Weight110.5461
Melting point: 162~166°C
| Item | Information |
|---|---|
| Mechanism of Action | Aminoguanidine hydrochloride is a selective inhibitor of nitric oxide synthase (NOS) and diamine oxidase. It inhibits both constitutive and inducible NOS, reducing the production of nitric oxide, which is involved in various physiological and pathological processes. |
| Indications | It is used for the study of diabetes-related complications, such as diabetic nephropathy. It is also used in research on alveolar bone loss in periodontitis and as an antitussive agent. |
| Formulations | Available as a crystalline powder, commonly dissolved in DMSO for laboratory use. |
| Dosage | The dosage varies depending on the specific research application. For example, in animal studies, it is often administered at doses ranging from 10 to 100 mg/kg. |
| Side Effects | Potential side effects include gastrointestinal disturbances and hepatotoxicity at high doses. |
| Research Applications | It is widely used in research related to nitric oxide signaling pathways, inflammation, and bacterial infections. |
| Storage Conditions | Store in a cool, dry place, protected from moisture and light. |
| Chemical Properties | White to off-white crystals, with a molecular formula of CH7ClN4 and a molecular weight of approximately 110.55 |
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