Ambrisentan
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID80071724
CAS NO.177036-94-1
Purity 98%
MDL NumberMFCD09842330
Molecular FormulaC22H22N2O4
Molecular Weight378.426
Melting point: 157~185°C
| Item | Information |
|---|---|
| Mechanism of Action | Ambrisentan is a selective endothelin receptor antagonist that blocks the effects of endothelin-1, a potent vasoconstrictor. By inhibiting the binding of endothelin-1 to its receptors, ambrisentan helps to dilate blood vessels in the lungs, reducing pulmonary arterial pressure. |
| Indications | Ambrisentan is used to treat pulmonary arterial hypertension (PAH) in adults with WHO Functional Class II or III symptoms. It helps improve exercise capacity and delay clinical worsening. It is also approved for use in combination with other medications, such as tadalafil. |
| Formulations | Available as oral tablets in 5 mg and 10 mg strengths. |
| Dosage | The initial dose is 5 mg once daily, which may be increased to 10 mg once daily if tolerated. It can be taken with or without food. |
| Side Effects | Common side effects include peripheral edema, nasal congestion, headache, and hot flashes. Serious side effects may include liver damage, anemia, and allergic reactions. |
| Contraindications | Contraindicated in pregnant women due to the risk of birth defects. It is also not recommended for patients with idiopathic pulmonary fibrosis. |
| Special Programs | Ambrisentan is available only through a restricted distribution program called the Ambrisentan REMS, which includes pregnancy testing and contraception requirements for women of childbearing potential. |
| Monitoring | Regular monitoring of liver function and hemoglobin levels is recommended, especially during the first month of treatment and periodically thereafter. |
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