Alitretinoin
We are a manufacturer based in China, specializing in high-quality Alitretinoin for industrial clients worldwide. Technical support and custom formulation available.
Category：Active Pharmaceutical Ingredients | Brand：MT
Factory Direct
7-30 Days Lead Time
MOQ: 100KG
Global Export
Introduction
Catalog ID80071722
CAS NO.5300-03-8
Purity 95%
MDL NumberMFCD00270072
Molecular FormulaC20H28O2
Molecular Weight300.439
Melting point: 179~184°C
| Item | Information |
|---|---|
| Mechanism of Action | Alitretinoin (9-cis-retinoic acid) is a retinoid receptor pan-agonist that binds to all six known retinoid receptors (RAR-α, -β, -γ, and RXR-α, -β, -γ). It regulates cellular differentiation, proliferation, and apoptosis, and has anti-inflammatory and immunomodulatory effects. |
| Indications | FDA-approved for the treatment of chronic hand eczema (CHE) and localized cutaneous Kaposi’s sarcoma (KS). It is also used off-label for conditions like photoaged skin and psoriasis. |
| Formulations | Available as oral capsules and topical gels (0.1% concentration). |
| Dosage | For CHE, the usual oral dose is 10-40 mg once daily for up to 24 weeks. For KS, topical gel is applied 2-4 times daily. |
| Side Effects | Common side effects include headache, dry skin, rash, and hyperlipidemia (oral form); local reactions like erythema and pruritus (topical form). |
| Contraindications | Pregnancy, lactation, hypersensitivity to alitretinoin, and concurrent use of tetracyclines. |
| Special Precautions | Women of childbearing potential must use reliable contraception during and for one month after treatment. Avoid sun exposure for topical formulations. |
| Drug Interactions | Potential interactions with CYP3A4 inhibitors (e.g., ketoconazole) and statins (e.g., simvastatin). Avoid concurrent use with vitamin A supplements. |
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