Alectinib
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Catalog ID92548
CAS NO.1256580-46-7
Purity 98%
MDL NumberMFCD19440988
Molecular Formula C30H34N4O2
Molecular Weight 482.617
| Category | Content |
|---|---|
| Generic Name | Alectinib |
| Brand Name | ALECENSA |
| Chemical Formula | C30H34N4O2·HCl |
| CAS Number | 1383516-62-8 |
| Mechanism of Action | Alectinib is a potent and selective ALK tyrosine kinase inhibitor that targets ALK and RET. It inhibits ALK phosphorylation and downstream signaling pathways, reducing tumor cell viability. |
| Indications | – Indicated for the treatment of ALK-positive metastatic non-small cell lung cancer (NSCLC) as detected by an FDA-approved test.<br>- Used in patients who have progressed on or are intolerant to crizotinib. |
| Dosage Forms | Capsules (150 mg) |
| Administration | – Recommended dose: 600 mg orally twice daily with food.<br>- For severe hepatic impairment (Child-Pugh C): 450 mg orally twice daily. |
| Pharmacokinetics | – High bioavailability when taken with food.<br>- Half-life: Approximately 33 hours.<br>- Metabolized primarily by CYP3A4. |
| Side Effects | – Common: Constipation, edema, myalgia, fatigue.<br>- Serious: Hepatotoxicity, interstitial lung disease/pneumonitis, bradycardia, elevated CPK levels. |
| Precautions | – Monitor liver function tests regularly.<br>- Use with caution in patients with severe hepatic impairment.<br>- Advise females of reproductive potential to use effective contraception. |
| Storage | Store at room temperature, protect from moisture. |
| Developer | Genentech, Inc. |
| Approval Date | FDA approval in 2015. |
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