Afoxolaner
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
English Synonyms 4-[5-[3-Chloro-5-(trifluoromethyl)phenyl]-4,5-dihydro-5-(trifluoromethyl)-3-isoxazolyl]-N-[2-oxo-2-[(2,2,2-trifluoroethyl)amino]ethyl]-1-naphthalene carboxamide
Catalog ID101535
CAS NO.1093861-60-9
Purity 99%
MDL NumberMFCD30533411
EINEC Molecular Formula C26H17ClF9N3O3
Molecular Weight 625.87
| Category | Content |
|---|---|
| Generic Name | Afoxolaner |
| Brand Name | NexGard, NexGard Spectra |
| Chemical Formula | C26H17ClF9N3O3 |
| Mechanism of Action | Afoxolaner is an isoxazoline that acts on ligand-gated chloride channels, particularly those gated by gamma-aminobutyric acid (GABA), blocking the transfer of chloride ions across cell membranes. This affects the nervous system of parasites, leading to their death. |
| Indications | Used to treat and control flea and tick infestations in dogs. It is also effective against demodicosis and sarcoptic mange. |
| Dosage Forms | Chewable tablets |
| Pharmacokinetics | Rapidly absorbed after oral administration, with peak blood levels reached within 2 to 12 hours. The mean half-life ranges from 7.7 to 17.8 days. |
| Side Effects | Generally well-tolerated, but may cause gastrointestinal disturbances in some cases. |
| Developer | Boehringer Ingelheim Vetmedica GmbH |
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