Pharmaceutical Materials

CAS Number: 73-24-5

Molecular Formula: C5H5N5

Molecular Weight: 135.13

Appearance: White to grayish-white crystalline powder

Usage: Essential component of DNA and RNA, involved in cellular respiration and energy metabolism.

Solubility: 0.5 g/L in water at 20°C.

 

Aspect	Details
Name	Adenine
Synonyms	6-Aminopurine; Vitamin B4 (historical); Purine-6-amine
CAS Number	73-24-5
Chemical Formula	C₅H₅N₅
Molecular Weight	135.13 g/mol
Physical Properties	– Appearance: White to off-white crystalline powder
	– Melting Point: 360–365°C
	– Solubility: Slightly soluble in water (0.5 g/L at 20°C), DMSO, acids, and bases
Biological Roles	– Nucleic Acids: Constituent of DNA and RNA (paired with thymine/uracil)
	– Energy Metabolism: Precursor to ATP, NAD⁺, and FAD
	– Protein Synthesis: Essential for codon-anticodon recognition
Synthetic Applications	– Antivirals: Intermediate in acyclovir and ganciclovir synthesis
	– Cytokines: Precursor to 6-benzyladenine (plant growth regulator)
Medical Uses	– Hematology: Treats leukopenia, especially post-chemotherapy
	– Research: Standard in nucleotide metabolism and enzyme kinetics studies
Safety Precautions	– Handling: Wear PPE; avoid inhalation and skin contact
	– Storage: Keep in airtight containers, away from light and moisture

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