Acyclovir CAS 59277-89-3
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
Molecular Formula: C8H11N5O3
Molecular Weight: 225.2
CAS No.: 59277-89-3
Description
It is a white or almost white, crystalline powder. It is slightly soluble in water, freely soluble in dimethyl sulfoxide, very slightly soluble in ethanol (96 per cent). It dissolves in dilute solutions of mineral acids and alkali hydroxides.
Application
It is a synthetic purine nucleoside analog. It is mainly used for various infections caused by herpes simplex virus. It can be used for HSV infection in newly diagnosed or recurrent skin, mucous membranes, external genital infections and immunodeficiency.
Packing and Storage
Preserve in tight containers. Store at room temperature. Protect from light and moisture.
Minimum Order
One package
| Item | Content |
|---|---|
| Introduction | Acyclovir (CAS 59277-89-3) is an antiviral medication used to treat infections caused by herpes viruses, including herpes simplex virus (HSV) and varicella-zoster virus (VZV). It is also used for prophylaxis in immunocompromised patients. |
| Chemical Information | – Molecular Formula: C₈H₁₁N₅O₃<br>- Molecular Weight: 225.2 |
| Chemical Name | 2-Amino-9-[(2-hydroxyethoxy)methyl]-1H-purin-6-one |
| Synonyms | Aciclovir, Acycloguanosine, Zovirax, 9-(2-hydroxyethoxymethyl)guanine |
| Mechanism of Action | Acyclovir is a deoxynucleoside analog that inhibits viral DNA polymerase, preventing DNA replication in herpes viruses. |
| Indications | – Herpes simplex infections (oral and genital)<br>- Varicella-zoster infections (chickenpox and shingles)<br>- Prophylaxis in immunocompromised patients |
| Dosage Forms | – Oral tablets and capsules<br>- Topical creams and ointments<br>- Intravenous solutions |
| Storage Conditions | – Store at -20°C for long-term stability.<br>- Protect from light and moisture. |
| Solubility | – Soluble in water at 0.7 mg/mL<br>- Soluble in 1M HCl at 50 mg/mL |
| Stability | Acyclovir remains stable in 0.9% NaCl infusion for at least 21 days at 5±3°C, with or without prior freezing at -20°C. |
| Common Side Effects | – Nausea, vomiting, headache, dizziness |
| Serious Side Effects | – Renal impairment (with high-dose intravenous use)<br>- Central nervous system effects (e.g., hallucinations, seizures) |
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