Acethydrazide
Agrochemicals 2025-03-02
Acethydrazide (CAS No. 1068-57-1)
1. Basic Information
- IUPAC Name: Acetic acid hydrazide
- Synonyms: Acetyl hydrazide; Ethanohydrazide
- CAS Number: 1068-57-1
- Molecular Formula: C₂H₆N₂O
- Molecular Weight: 74.08 g/mol
- Appearance: White crystalline powder
- Odor: Odorless
2. Physical and Chemical Properties
| Property | Value |
|---|---|
| Melting Point | 65–68°C (149–154°F) |
| Boiling Point | Decomposes before boiling |
| Density | 1.17 g/cm³ (20°C) |
| Solubility | – Water: Highly soluble |
| – Ethanol: Soluble | |
| – Ether: Insoluble | |
| pKa | ~3.5 (hydrazide proton) |
3. Chemical Structure
O ║ CH₃-C-NH-NH₂
4. Hazards (GHS Classification)
- Acute Toxicity:
- Oral LD₅₀ (rat): 500–1,000 mg/kg (Category 4)
- Skin Irritation: May cause mild irritation (H315)
- Environmental: Not classified
5. Storage and Handling
- Storage:
- Tightly sealed in cool, dry place
- Protect from moisture and oxidizing agents
- Handling:
- Use nitrile gloves and safety goggles
- Avoid dust formation
6. Applications
- Pharmaceuticals: Intermediate for antibiotics (e.g., isoniazid derivatives)
- Organic Synthesis: Precursor for heterocycles (triazoles, oxadiazoles)
- Polymer Chemistry: Chain extender for polyurethanes
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