abrutinib CAS NO.1622902-68-4
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Category：Active Pharmaceutical Ingredients Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
| Name | Abrocitinib |
| Synonyms | PF04965842 Abrocitinib ABROCITINIB PF04965842 PF-04965842 PF 04965842 ABROCITINIB PF 04965842 PF-04965842(Abrocitinib) ABROCITINIB (PF-04965842) N-[cis-3-(Methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)cyclobutyl]-1-propanesulfonamide rel-N-((1s,3s)-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)cyclobutyl)propane-1-sulfonamide |
| CAS | 1622902-68-4 |
| Molecular Formula | C14H21N5O2S |
| Molar Mass | 323.41 |
| Density | 1.36±0.1 g/cm3(Predicted) |
| Appearance | powder |
| Color | white to beige |
| pKa | 10.55±0.40(Predicted) |
| Storage Condition | room temp |
| In vivo study | In rats, by intravenous injection of 1 mg/kg or oral administration of 3 mg/kg PF-04965842, its clearance in vivo is low relative to the overall hepatic blood flow, CL = 26.6/min/kg, vdss = 1.04 L/kg,T 1/2=1.1 h. The oral bioavailability was 95.6% PF-04965842. In a rat model of adjuvant arthritis, PF-04965842 had a dose-dependent effect. |
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