7-Fluoro-6-nitro-4-hydroxyquinazoline
Pharmaceutical Materials 2025-03-02
CAS Number: 162012-69-3
Molecular Formula: C8H4FN3O3
Molecular Weight: 209.13 g/mol
Appearance: White or light yellow powder
Usage: It is an important intermediate in the synthesis of pharmaceuticals, especially in the production of afatinib.
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| Property | Details |
|---|---|
| Chemical Name | 7-Fluoro-6-nitro-4-hydroxyquinazoline |
| CAS Number | 162012-69-3 |
| Synonyms | 7-Fluoro-6-nitro-4(H)-quinazolinone; 7-Fluoro-6-nitroquinazolin-4-ol; 6-Nitro-7-fluoroquinazolin-4(1H)-one; 7-Fluoro-6-nitro-3.4-dihydroquinazolin-4-one; 7-FLUORO-6-NITRO-4-HYDROXY-QUINAZOLINE |
| Molecular Formula | C8H4FN3O3 |
| Molecular Weight | 209.13 g/mol |
| Chemical Structure | A heterocyclic compound with a quinazoline ring, where the 7-position is substituted with fluorine, the 6-position is substituted with a nitro group, and the 4-position has a hydroxyl group. |
| Physical State | Solid |
| Color | White or off-white |
| Melting Point | Not specifically reported, but typical for similar compounds |
| Solubility | Soluble in organic solvents such as DMSO, DMF, and ethanol |
| Stability | Stable under normal conditions. Store in a cool, dry place, away from direct sunlight and incompatible materials. |
| Applications | Used as an intermediate in the synthesis of pharmaceutical compounds, particularly in the production of certain anticancer or anti-inflammatory drugs. It may also have potential applications in other fields such as agriculture or materials science. |
| Safety Information | Handle with care. Wear appropriate personal protective equipment when handling. Keep away from incompatible materials, heat, sparks, and open flames. Refer to the Material Safety Data Sheet (MSDS) for detailed safety information. |
