6-(Trifluoromethyl)nicotinonitrile
Pharmaceutical Materials 2025-03-02
CAS Number: 216431-85-5
Molecular Formula: C7H3F3N2
Molecular Weight: 172.11 Appearance: White to light yellow powder
Melting Point: 37-41°C
Boiling Point: 200.8°C (at 760 mmHg)
Usage: Widely used as an intermediate in the pharmaceutical industry.
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| Property | Details |
|---|---|
| Chemical Name | 6-(Trifluoromethyl)nicotinonitrile |
| CAS Number | 216431-85-5 |
| Synonyms | 3-Cyano-6-(trifluoromethyl)pyridine; 5-Cyano-2-(trifluoromethyl)pyridine |
| Molecular Formula | C7H3F3N2 |
| Molecular Weight | 172.11 g/mol |
| Appearance | Colorless to pale yellow crystalline solid |
| Density | 1.4±0.1 g/cm³ |
| Melting Point | 37-41°C |
| Boiling Point | 200.8±40.0°C at 760 mmHg |
| Flash Point | 75.2±27.3°C |
| Refractive Index | 1.457 |
| Vapor Pressure | 0.3±0.4 mmHg at 25°C |
| Solubility | Soluble in organic solvents |
| LogP | 1.88 |
| PSA | 36.68000 Ų |
| Applications | Used as an intermediate in the synthesis of various organic compounds, particularly in the pharmaceutical and agrochemical industries. It serves as a key building block for the preparation of heterocyclic compounds with trifluoromethyl substitution. |
| Safety | Handle with care. May be harmful if swallowed or inhaled. Wear appropriate personal protective equipment when handling. Keep away from incompatible materials, heat, sparks, and open flames. |
