5-(Trifluoromethyl)pyridin-2-amine
Pharmaceutical Materials 2025-03-02
CAS Number: 74784-70-6
Molecular Formula: C6H5F3N2
Molecular Weight: 162.11 g/mol
Appearance: White to off-white powder or crystalline solid
Melting Point: 45-50 °C
Boiling Point: 208.2 °C at 760 mmHg
Density: 1.368 g/cm3
Usage: Used as an intermediate in the synthesis of pharmaceuticals and agrochemicals.
| Aspect | Details |
|---|---|
| Name | 5-(Trifluoromethyl)pyridin-2-amine |
| CAS Number | 74784-70-6 |
| Chemical Formula | C₆H₅F₃N₂ |
| Molecular Weight | 162.11 g/mol |
| Physical Appearance | White to light yellow crystalline solid |
| Melting Point | 45-47°C |
| Boiling Point | 90-92°C at 20 mbar |
| Flash Point | 104°C |
| Density | 1.71 g/cm³ |
| Reactivity | Stable under normal conditions; reactive towards acids and bases. |
| Solubility | Soluble in chloroform and methanol (slightly). |
| Applications | – Key intermediate in pharmaceuticals, particularly for cardiovascular drugs. |
| – Used in agrochemicals and specialty chemicals. | |
| Safety Information | – Harmful if swallowed; causes skin and eye irritation (GHS Category 3). |
| – Flammable solid; handle with appropriate PPE. | |
| Storage Conditions | Store in a cool, dry, and inert atmosphere (2-8°C) to prevent degradation. |
| Purity (Reagent Grade) | 95%-99% |
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