5-Chlorothiophene-2-carboxylic acid Cas: 24065-33-6
Category：Pharmaceutical Materials
Introduction
Synonyms: 5-Chloro-2-thiophenecarboxylic acid Molecular Formula: C5H3ClO2S Molecular Weight: 162.59 CAS Registry Number: 24065-33-6
Name: 5-Chlorothiophene-2-carboxylic acid
Cas: 24065-33-6
Appearance: yellowish powder
Assay: ≥99%
Capacity: 100mt/year
Min.package: 1gram
Application: Rivaroxaban intermediate
Standard: enterprise export
2-chlorothiophene-5-carboxylic acid is a yellow to brown solid with a unique sulfur odor. It is only slightly soluble in water at room temperature, but can dissolve in organic solvents.
Purpose:
2-chlorothiophene-5-carboxylic acid is often used as an intermediate in organic synthesis, especially in the preparation of thiophene compounds, which has important application value. It can also be used as a dye, photosensitizer, fluorescent analysis reagent, etc.
Manufacturing method:
There are many methods for preparing 2-chlorothiophene-5-carboxylic acid, and one common method is to react 2-chlorothiophene with methanol in the presence of sodium hydroxide to produce 2-chlorothiophene-5-methanol. Then, under the action of an acid catalyst, the methanol group is converted to a carboxyl group to obtain 2-chlorothiophene-5-methyl acid.
Security information:
2-chlorothiophene-5-carboxylic acid is irritating and should be avoided from contact with skin, eyes, and mucous membranes. During operation, personal protective equipment such as chemical protective gloves, glasses, and face shields should be worn to ensure sufficient ventilation conditions. Attention should be paid to avoiding contact with strong oxidants and acidic substances to prevent accidental reactions. During storage and transportation, it is necessary to avoid high temperatures and sources of fire.
| Name | 5-Chloro-2-thiophenecarboxylic acid |
| Synonyms | AKOS B000092 Rivaroxaban Impurity N Chlorothiophene-2-carboxy 2-Chlorothiophene-5-formicacid 5-chlorothiophene-2-carboxylate 5-chloro-2-thiophenecarboxylicaci 5-CHLORO-2-THIOPHENECARBOXYLIC ACID 2-chlorothiophene-5-carboxylic acid 5-Chloro-2-thiophenecarboxylic acid 5-Chlorothiophene-2-carboxylic acid 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID 5-Chlorothiophene-2-carboxilic acid 5-Chloro-2-thiophene carboxylic acid 2-Thiophenecarboxylic acid, 5-chloro- |
| CAS | 24065-33-6 |
| EINECS | 000-000-0 |
| InChI | InChI=1/C5H3ClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)/p-1 |
| InChIKey | QZLSBOVWPHXCLT-UHFFFAOYSA-N |
| Molecular Formula | C5H3ClO2S |
| Molar Mass | 162.59 |
| Density | 1.466 (estimate) |
| Melting Point | 154-158°C(lit.) |
| Boling Point | 287.0±20.0 °C(Predicted) |
| Flash Point | 127.4°C |
| Solubility | DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 0.00119mmHg at 25°C |
| Appearance | White solid |
| Color | Cream-yellow |
| BRN | 118361 |
| pKa | 3.32±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
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