5-Chloro-2-nitroaniline
Agrochemicals 2025-03-02
5-Chloro-2-nitroaniline (CAS No. 6283-25-6)
1. Basic Information
- IUPAC Name: 5-Chloro-2-nitroaniline
- Synonyms:
- 2-Amino-4-chloronitrobenzene
- 2-Nitro-5-chloroaniline
- CAS Number: 6283-25-6
- Molecular Formula: C₆H₅ClN₂O₂
- Molecular Weight: 172.57 g/mol
- Appearance: Yellow to orange crystalline powder
- Odor: Slight aromatic odor
2. Physical and Chemical Properties
| Property | Value |
|---|---|
| Melting Point | 116–119°C (241–246°F) |
| Boiling Point | Decomposes before boiling |
| Density | 1.45 g/cm³ (20°C) |
| Solubility | – Water: Insoluble |
| – Organic solvents: Soluble in ethanol, acetone, DMSO | |
| Log Pow | 2.1 (octanol/water) |
| Vapor Pressure | <0.1 mPa at 25°C |
3. Chemical Structure
Cl
|
NO₂-◯-NH₂
(◯ = benzene ring with substitutions at positions 1, 2, and 4)
4. Hazards (GHS Classification)
- Acute Toxicity:
- Harmful if swallowed (H302)
- Causes skin irritation (H315)
- Causes serious eye irritation (H319)
- Environmental:
- Toxic to aquatic life (H411)
- NFPA Rating: Health 2, Flammability 1, Reactivity 1
5. Storage and Handling
- Storage:
- Keep in tightly sealed amber containers
- Store in a cool, dry, well-ventilated area
- Handling:
- Use nitrile gloves, safety goggles, and a fume hood
- Avoid dust formation
6. Applications
- Dye Intermediate:
- Synthesis of azo dyes and pigments
- Agrochemicals:
- Building block for pesticides
- Pharmaceuticals:
- Precursor for antimicrobial agents
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