[5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-yl]amine Cas：877399-00-3
Pharmaceutical Materials 2025-03-02
[5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-yl]amine, with the CAS number 877399-00-3, is a complex organic compound that possesses significant importance in the field of pharmaceutical chemistry. This compound features a pyridine ring substituted with a 5-bromo group, a 3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy] group at the 3-position, and an amine group at the 2-position.
Due to its unique structure, this compound serves as a key intermediate in the synthesis of various pharmaceutical agents, particularly in the development of anticancer drugs. It is typically a white or off-white powder with high purity and stability. [5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-yl]amine has been identified as an intermediate in the synthesis of crizotinib, a tyrosine kinase inhibitor used in the treatment of non-small cell lung cancer.
| Product Information | Details |
|---|---|
| Compound Name | [5-Bromo-3-[(1R)-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-2-yl]amine |
| CAS Number | 877399-00-3 |
| Molecular Formula | C13H10BrCl2FN2O |
| Molecular Weight | 380.04 g/mol |
| Physical State | White or off-white powder |
| Purity | ≥98% |
| Melting Point | N/A (Decomposes before melting) |
| Boiling Point | 423.4 °C at 760 mmHg (Predicted) |
| Density | 1.643 g/cm³ |
| LogP | 5.593 |
| PSA | 48.14 Ų |
| Usage | Pharmaceutical intermediate, particularly in the synthesis of anticancer drugs |
| Storage Conditions | Store in a cool, dry place, away from light and moisture |
| Stability | Stable under recommended storage conditions |
| Hazard Information | Potential skin and eye irritant, handle with care |
,Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
