(5-Bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]methanone CAS NO.:1132832-75-7
Pharmaceutical Materials 2025-03-02
Catalog ID:101177
CAS NO.:1132832-75-7
Purity:95%
MDL Number:MFCD25977368
Molecular Weight:375.26
(5-Bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]methanone is a chemical compound primarily used as an intermediate in the synthesis of pharmaceuticals, particularly in the production of antidiabetic drugs like canagliflozin. This compound features a bromine atom and a fluorine atom substituted on aromatic rings, connected through a carbonyl group to a thiophene ring. Its complex structure imparts unique reactivity, making it an essential building block in organic synthesis.
| Property | Details |
|---|---|
| CAS Number | 1132832-75-7 |
| Chemical Name | (5-Bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]methanone |
| Synonyms | (5-Bromo-2-methylphenyl)(5-(4-fluorophenyl)thiophen-2-yl)methanone, (5-Bromo-2-methylphenyl)[5-(4-fluorophenyl)-2-thienyl]methanone |
| Molecular Formula | C18H12BrFOS |
| Molecular Weight | 375.255 g/mol |
| Appearance | Reddish-brown solid or powder |
| Density | 1.448 ± 0.06 g/cm³ (predicted) |
| Melting Point | 121-122 °C |
| Boiling Point | 476.0 ± 45.0 °C at 760 mmHg |
| Flash Point | 241.7 ± 28.7 °C |
| Refractive Index | 1.625 |
| PSA | 45.310 Ų |
| LogP | 5.85610 |
| Uses | Pharmaceutical intermediate in the synthesis of antidiabetic drugs |
| Storage Conditions | Keep in a cool, dry place, away from direct sunlight and sources of ignition. |
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