4,6-Dichloro-2-propylthiopyrimidin-5-amine CAS Number: 145783-15-9
Pharmaceutical Materials 2025-03-02
Molecular Formula: C7H9Cl2N3S
Molecular Weight: 238.14 g/mol
Appearance: Solid, usually described as white, colorless, or brown powder
Density: 1.445 g/cm³
Boiling Point: 334.05°C at 760 mmHg
Usage: It is an important intermediate in the production of anticoagulant drugs, such as Ticagrelor.
4,6-Dichloro-2-propylthiopyrimidin-5-amine, with the CAS number 145783-15-9, is a significant organic compound primarily recognized as an intermediate in the synthesis of the anticoagulant drug ticagrelor. This amino-substituted pyrimidine derivative exhibits specific reactivity patterns due to its dichlorinated and propylthio-substituted structure. It is widely employed in laboratory and industrial settings for the development and production of pharmaceuticals. The compound’s stability and solubility properties make it a valuable asset in the chemical synthesis of complex molecules.
| Property Category | Details |
|---|---|
| Chemical Name | 4,6-Dichloro-2-propylthiopyrimidin-5-amine |
| CAS Number | 145783-15-9 |
| Molecular Formula | C7H9Cl2N3S |
| Molecular Weight | 238.14 g/mol |
| Physical Properties | |
| Appearance | Powder to block to transparent liquid, white or colorless to brown |
| Density | 1.44 g/cm³ |
| Boiling Point | 334.1±37.0 °C (predicted) |
| Solubility | Soluble in methanol; 100 mg/L at 22°C in water |
| Chemical Properties | Amino-substituted pyrimidine; reacts with electrophiles at the amino group and halogen atoms |
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