Pharmaceutical Materials

Product Name

4-(Trifluoromethyl)Benzaldehyde

4-Multiple Names

(Trifluoromethyl)Benzaldehyde;

p-(Trifluoromethyl)Benzaldehyde;

p-Trifluoromethylbenzaldehyde;

p-(Trifluoromethyl) Benzaldehyde;

4-(Trifluoromethy)Benzaldehyde;

4-(Trifluoromethyl)-Benzaldehyde;

4-Trifluoromethylbenzaldehyde;

4-(Trifluoromethyl) Benzaldehyde

CAS No. 455-19-6

EC No. 207-240-7

MF No. C8H5F3O

MW No. 174.1199

It is widely used as a pesticide intermediate and a kinetic research reagent in wittig reaction and alcohol asymmetric synthesis reaction.

Advantage of 4-(Trifluoromethyl) Benzaldehyde CAS No. 455-19-6

Shape stability

Easy to stock

Significant effect in the pharmaceutical industry

Names and Identifiers

Name	alpha,alpha,alpha-Trifluoro-p-tolualdehyde
Synonyms	PTF-BAD 4-Trifluoromethylbenzaldehyde p-Trifluoromethylbenzaldehyde P-TRIFLUOROMETHYLBENZALDEHYDE α,α,α-Trifluoro-p-tolualdehyde 4-(trifluoromethy)benzaldehyde A,A,A-TRIFLUORO-P-TOLUALDEHYDE 4-(Trifluoromethyl)benzaldehyde P-(TRIFLUOROMETHYL)-BENZALDHYDE p-(Trifluoromethyl)benzaldehyde 4′-TRIFLUOROMETHYL BENZALDEHYDE 4-(TRIFLUOROMETHYL)BENZALDEHYDE p-(Trifluoromethyl) benzaldehyde 4-(Trifluoromethyl) benzaldehyde 4-(Trifluoromethyl)-benzaldehyde alpha,alpha,alpha-Trifluoro-p-tolualdehyde p-(Trifluoromethyl)benzaldehyde 4-(Trifluoromethyl)benzaldehyde
CAS	455-19-6
EINECS	207-240-7
InChI	InChI=1/C8H5F3O/c9-8(10,11)7-3-1-6(5-12)2-4-7/h1-5H
InChIKey	BEOBZEOPTQQELP-UHFFFAOYSA-N

​Physico-chemical Properties

Molecular Formula	C8H5F3O
Molar Mass	174.12
Density	1.275g/mLat 25°C(lit.)
Melting Point	1-2°C
Boling Point	66-67°C13mm Hg(lit.)
Flash Point	150°F
Water Solubility	Soluble in water. 1.5 g/L at 20°C
Solubility	1.5g/l
Vapor Presure	1.09mmHg at 25°C
Appearance	Transparent liquid
Specific Gravity	1.275
Color	Clear colorless to yellow
BRN	1101680
Storage Condition	Inert atmosphere,2-8°C
Sensitive	Air Sensitive
Refractive Index	n20/D 1.463(lit.)
MDL	MFCD00006952
Physical and Chemical Properties	Density 1.275 boiling point 66-67 ° C (13 mmHg) flash point 65°C
Use	Used in exercise studies in the Wittig reaction and in the asymmetric synthesis of alcohol.

Risk and Safety

Hazard Symbols	Xi – Irritant
Risk Codes	36/37/38 – Irritating to eyes, respiratory system and skin.
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36 – Wear suitable protective clothing.
WGK Germany	3
FLUKA BRAND F CODES	10-23
TSCA	T
HS Code	29130000
Hazard Note	Irritant
Hazard Class	IRRITANT, AIR SENSIT

Reference Information

Synthesis method

Using p-trifluoromethylaniline as raw material, p-trifluoromethylbenzaldehyde is prepared by diazotization, oxime, and hydrolysis. The yield is 35.9%. The mixed solution of halogenated hydrocarbon additive and p-trifluoromethylchlorobenzene is slowly added to the tetrahydrofuran solution impregnated with magnesium chips to synthesize the Grignard reagent of p-trifluoromethylchlorobenzene; N,N-dimethylformamide is added to the Grignard reagent of p-trifluoromethyl chlorobenzene to react to obtain this product.

Use

Kinetic research reagents for Wittig reactions and asymmetric synthesis reactions of alcohols

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