4-Trans-Propylcyclohexylphenylboronic acid
Semiconductor Display Materials 2025-03-04
4-Trans-Propylcyclohexylphenylboronic acid is an organoboron compound characterized by a propylcyclohexyl substituent on the phenyl ring and a boronic acid group. This compound is of significant interest in organic synthesis and material science due to its unique structure and versatile reactivity.
Key Properties
| Property | Details |
|---|---|
| IUPAC Name | 4-Trans-Propylcyclohexylphenylboronic acid |
| CAS Number | 146862-02-4 |
| Molecular Formula | C₁₅H₂₃BO₂ |
| Molecular Weight | 246.15 g/mol |
| Appearance | White powder |
| Density | 1.03 g/cm³ |
| Boiling Point | ~394.9°C |
| Acidity (pKa) | 8.70±0.17 (predicted) |
| Synthesis Method | Palladium-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura coupling) |
| Applications | Organic synthesis, medicinal chemistry, development of novel pharmaceuticals |
Synthesis
4-Trans-Propylcyclohexylphenylboronic acid can be synthesized via palladium-catalyzed cross-coupling reactions, such as the Suzuki-Miyaura coupling. This method involves the reaction of a brominated phenylboronic acid with a bromopropylcyclohexane, facilitated by a palladium catalyst, to construct the propylcyclohexylphenylboronic acid efficiently.
Applications
In organic synthesis, 4-Trans-Propylcyclohexylphenylboronic acid serves as a valuable building block for the preparation of complex molecules, particularly those requiring defined stereochemistry and functionality. The propylcyclohexylphenyl structure makes it a promising candidate for the development of novel pharmaceuticals, agrochemicals, and functional materials. The boronic acid moiety can be further transformed into other functional groups, expanding the scope of its applications.
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
