4-Nitro-2,3-lutidine-N-oxide
Pharmaceutical Materials 2025-03-02
CAS Number: 37699-43-7
Molecular Formula: C7H8N2O3
Molecular Weight: 168.15 g/mol
Appearance: Light yellow powder
Melting Point: 94-98°C (lit.)
Usage: It is used as an intermediate in pharmaceutical synthesis, especially in the production of lansoprazole.
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| Attribute | Information |
|---|---|
| Chemical Name | 4-Nitro-2.3-lutidine-N-oxide |
| CAS Number | 555-16-8 |
| Synonyms | 4-Nitro-2.3-pyridinedimethanol N-oxide; 4-Nitro-N-oxido-2.3-lutidine; 4-Nitro-N-oxido-2.3-pyridinecarboxaldehyde hydrate |
| Molecular Formula | C6H6N2O3 |
| Molecular Weight | 154.12 g/mol |
| Appearance | Yellowish crystalline solid |
| Melting Point | 168-172 °C |
| Solubility | Soluble in polar solvents such as water, ethanol, and acetonitrile; insoluble in non-polar solvents like ether and benzene |
| Chemical Structure | Contains a pyridine ring with a nitro group at the 4-position and an N-oxide moiety at the nitrogen atom |
| Synthesis Methods | Prepared by the oxidation of 4-nitro-2.3-lutidine with hydrogen peroxide or other oxidizing agents. |
| Properties | Exhibits acidic properties due to the presence of the N-oxide group, which can undergo base-catalyzed reactions. |
| Uses | Used as an intermediate in the synthesis of organic compounds and pharmaceuticals. It can also be used as a ligand in coordination chemistry. |
| Health Effects | May cause irritation to skin, eyes, and respiratory tract. Ingestion may be harmful. |
| Environmental Considerations | Handle and dispose of 4-Nitro-2.3-lutidine-N-oxide according to local environmental regulations. |
| Safety Precautions | Wear appropriate protective clothing and eye protection. Store in a cool, dry place, away from heat, sparks, and open flames. |
