4-Morpholino piperidine
Pharmaceutical Materials 2025-03-02
Catalog ID:825903
CAS NO.:53617-35-9
Purity:98%
Molecular Weight:170.25
| Chemical Name | 4-Morpholino piperidine; 4-(4-Piperidinyl)morpholine |
| CAS No. | 53617-35-9 |
| Molecular Formula | C₉H₁₈N₂O |
| Molecular Weight | 170.25 g/mol |
| Appearance | White solid (powder/crystalline) at room temperature |
| Melting Point | 40-43°C |
| Boiling Point | 256.3°C (atmospheric pressure); 100-115°C (under 0.15-0.20 mmHg) |
| Density | 1.033 g/cm³ |
| Solubility | Soluble in water and organic solvents (e.g., methanol, dichloromethane) |
| Synthesis | Prepared via reductive amination of N-Boc-4-piperidone with morpholine, followed by deprotection |
| Applications | Pharmaceutical intermediate: Synthesis of adenosine A2A receptor antagonists, antidepressants, P2Y12 antagonists (antiplatelet agents), and antimicrobial quinoline derivatives. Also used in antimalarial drug development. |
| Safety Information | GHS Hazard Statements: H315 (skin irritant), H319 (serious eye irritant), H335 (may cause respiratory irritation). Precautions: Avoid inhalation (P261), wear gloves/goggles (P280), and clean thoroughly after handling (P264). Store in a sealed container at 2-8°C. |
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