Pharmaceutical Materials

4-Methylsulphonyl benzaldehyde, also known as p-methylsulfonylbenzaldehyde, is a crucial organic compound widely utilized as a pharmaceutical intermediate. Its molecular structure features a benzaldehyde core substituted with a methylsulfonyl group, imparting unique reactivity for synthesizing antibiotics and antimicrobial agents. Notably, it serves as a key precursor in the production of thiamphenicol, a broad-spectrum antibiotic. Beyond pharmaceuticals, its derivatives exhibit potential bioactivities, including antibacterial and antifungal properties. Physically, it manifests as a yellow to light brown crystalline powder, stable under ambient conditions but requiring storage in cool, dry environments to prevent degradation. With a melting point of 155–161 °C and solubility in organic solvents, its handling necessitates caution due to compatibility issues with strong oxidizers. Its synthesis and applications underscore its significance in medicinal chemistry and related industries.

Usage: Used as a pharmaceutical intermediate

Packaging and Shipping： 25kg/drum or as per buyer’s requirements.

Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.

 

Name	4-Methylsulfonyl benzaldehyde
Synonyms	4-Mesylbenzaldehyde 4-Methylsulphonyl be P-methylsufonyl benzaldehyde Of thiaMphenicol benzaldehyde 4-Methylsulfonyl benzaldehyde 4-Formylphenyl methyl sulphone 4-Methylsulphonyl Benzaldehyde 4-(METHYLSULFONYL)BENZALDEHYDE Benzaldehyde,4-(Methylsulfonyl)-
CAS	5398-77-6
EINECS	674-175-2
InChI	InChI=1/C8H8O3S/c1-12(10,11)8-4-2-7(6-9)3-5-8/h2-6H,1H3

Molecular Formula	C8H8O3S
Molar Mass	184.21
Density	1.3761 (rough estimate)
Melting Point	155-161 °C
Boling Point	288.16°C (rough estimate)
Flash Point	242.1°C
Solubility	Chloroform, Methanol
Vapor Presure	6.35E-06mmHg at 25°C
Appearance	Bright brown crystal
Color	Light yellow-beige to light brown
Storage Condition	under inert gas (nitrogen or Argon) at 2-8°C
Stability	Hygroscopic
Refractive Index	1.5151 (estimate)
MDL	MFCD00216485
Physical and Chemical Properties	Crystallization (aqueous ethanol). Melting point 158-159 °c.

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