Pharmaceutical Materials

4′-Ethylpropiophenone (CAS No. 27465-51-6) is a versatile organic compound widely used as a pharmaceutical intermediate, particularly in the synthesis of eperisone hydrochloride, a muscle relaxant. With a molecular formula of C11H14O and a molecular weight of 162.23 g/mol, it appears as a colorless liquid with a faint odor. This compound is stable under normal conditions but reacts with oxidizing agents and acids. It has a boiling point of 246°C and a density of 0.98 g/cm³. Safety data indicates it is classified as Xi (Irritant) under GHS, requiring protective measures during handling. Its applications extend to fragrances and flavors, leveraging its aromatic properties. Industrial synthesis often employs Friedel-Crafts acylation, yielding high-purity products suitable for pharmaceutical and chemical industries.

Usage： Used asPharmaceutical Intermediates.

Packaging and Shipping： 25KG/drum or as per buyer’s requirements.

Storage: Storage in ventilated low temperature dry warehouse; Keep container closed and separately from open flame and heat source.

Nature:

-Appearance: 4-Ethylpropiophenone is a colorless to pale yellow liquid.

-Odor: has a special aromatic smell.

-Density: about 0.961g/cm³.

-Boiling point: About 248 ° C.

-Solubility: Soluble in ethanol, ether and Ester solvents, insoluble in water.

Use:

-Industrial use: 4-Ethylpropiophenone is used as an intermediate in chemical synthesis in certain industrial fields.

-Chemical synthesis: It can be used to synthesize other compounds, such as drugs, pesticides and spices.

-Cosmetics and fragrances: Due to its aromatic properties, 4-Ethylpropiophenone can be used as an ingredient in cosmetics and fragrances.

Method:

1. Mix acetophenone and ethyl acetate in an appropriate proportion.

2. Condensation is carried out through acid-catalyzed reaction under appropriate temperature and reaction conditions.

3. Through heating and distillation, the target compound 4-Ethylpropiophenone is extracted from the reaction mixture.

Please note that you need to pay attention to safe operation during the preparation process, avoid contact with skin and inhalation of volatiles, and use appropriate protective equipment and ventilation conditions.

Safety Information:

4-Ethylpropiophenone is a chemical substance, should pay attention to the following safety matters:

-Avoid contact with skin and eyes. Wear protective gloves, goggles and protective clothing during operation.

-Avoid inhaling volatiles. During operation, good ventilation conditions should be ensured.

-Store in a dry, ventilated place, away from fire and high temperature.

-When using the compound, it should be operated in accordance with the operation manual and relevant safety regulations.

Name	4-Ethylpropiophenone
Synonyms	4-ETHYLPHENYLACETONE p-ethylpropiophenone 4-Ethylpropiophenone 4-cthyl proplophenone 4′-ETHYLPROPIOPHENONE ETHYL 4-ETHYLPHENYL KETONE 1-(4-Ethylphenyl)propan-2-one 1-(4-Ethylphenyl)-1-propanone 1-(4-ethylphenyl)-2-propanone 1-(4-ethylphenyl)propan-2-one 1-(4-ETHYL-PHENYL)-PROPAN-1-ONE 2-Propanone, 1-(4-ethylphenyl)-
CAS	27465-51-6 75251-24-0 16819-97-7
InChI	InChI=1/C11H14O/c1-3-10-4-6-11(7-5-10)8-9(2)12/h4-7H,3,8H2,1-2H3

Molecular Formula	C11H14O
Molar Mass	162.23
Density	0.961±0.06 g/cm3 (20 ºC 760 Torr)
Boling Point	241.0±9.0℃ (760 Torr)
Flash Point	101.3±7.3℃
Vapor Presure	0.0368mmHg at 25°C
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.5120

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