4- [difluoro (3,4,5-trifluorophenoxy) methyl] -2 ‘, 3,5-trifluoro-4’ ‘- propyl-1,1’: 4 ‘, 1’ ‘- triphenylene

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Introduction

 

Section Details
Chemical Structure Name: 4-[Difluoro(3.4.5-trifluorophenoxy)methyl]-2′,3.5-trifluoro-4”-propyl-1.1′:4′,1”-terphenyl
Formula: C₃₀H₂₂F₈O
CAS No.: 916156-32-6
Molecular Weight: 550.48 g/mol
Appearance: White/off-white powder.
Physical Properties Solubility: Likely soluble in polar solvents (e.g., methanol) due to fluorinated groups.
Supplier Availability: Commercially available from TCI, Aladdin, and others in purities ≥98%, with packaging from 250 mg to 100 g.
Chemical Properties Stability: Fluorination enhances thermal and chemical stability.
Reactivity: Fluorine substituents reduce nucleophilicity but may allow electrophilic aromatic substitution under harsh conditions.
Synthesis Methods Likely involves multi-step coupling reactions (e.g., Suzuki-Miyaura cross-coupling or nucleophilic substitution) to link fluorinated aromatic rings and install the difluoromethoxy group. Specific protocols require further literature review.
Applications Pharmaceuticals: Serves as an intermediate for synthesizing fluorinated drugs (e.g., antifungals, anti-inflammatories).
Materials Science: Potential use in liquid crystals or electronic materials due to fluorination-induced anisotropic properties.
Research: Model compound to study fluorine effects on molecular conformation, metabolic stability, and membrane permeability.

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