4-Chloropyrrolo[2,3-d]pyrimidine Cas：3680-69-1
Pharmaceutical Materials 2025-03-02
4-Chloropyrrolo[2,3-d]pyrimidine, with the CAS number 3680-69-1, is a versatile chemical compound with significant applications in the pharmaceutical industry. This heterocyclic compound features a chlorine atom substituted at the 4-position of the pyrrolo[2,3-d]pyrimidine ring, conferring unique chemical and biological properties.
It serves as an important intermediate in the synthesis of various pharmaceutical agents, most notably as an intermediate in the production of tofacitinib, a Janus kinase (JAK) inhibitor used to treat moderate to severe rheumatoid arthritis. 4-Chloropyrrolo[2,3-d]pyrimidine is typically a white to off-white powder with high purity and stability, making it suitable for use in demanding synthetic processes.
| Product Information | Details |
|---|---|
| Compound Name | 4-Chloropyrrolo[2,3-d]pyrimidine |
| CAS Number | 3680-69-1 |
| Molecular Formula | C6H4ClN3 |
| Molecular Weight | 153.57 g/mol |
| Physical State | White to off-white powder |
| Purity | ≥97% |
| Density | 1.389 g/cm³ |
| Melting Point | 186-189 °C |
| Boiling Point | 332.5 °C at 760 mmHg |
| Flash Point | 154.9 °C |
| Vapor Pressure | 0.000145 mmHg at 25 °C |
| Solubility | Soluble in DMSO, ethyl acetate, and methanol |
| Usage | Pharmaceutical intermediate, especially in the synthesis of tofacitinib |
| Storage Conditions | Keep in a cool, dry place, away from light and moisture |
| Stability | Stable under recommended storage conditions |
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