4-Chlorophenethylamine
Pharmaceutical Materials 2025-03-02
CAS Number: 156-41-2
Molecular Formula: C8H11ClN
Molecular Weight: 155.63 g/mol
Appearance: Clear colorless to yellow liquid
Boiling Point: 242-245°C
Density: 1.112 g/mL
Usage: It is used as an intermediate in chemical synthesis.
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| Attribute | Information |
|---|---|
| Chemical Name | 4-Chlorophenethylamine |
| CAS Number | 53-49-0 |
| Synonyms | 2-(4-Chlorophenyl)ethanamine; 4-Chlorophenylethylamine; p-Chlorophenethylamine |
| Molecular Formula | C8H10ClN |
| Molecular Weight | 155.62 g/mol |
| Appearance | Colorless to slightly yellow oily liquid |
| Melting Point | -45 °C |
| Boiling Point | 247-249 °C |
| Density | 1.13 g/mL at 25 °C |
| Refractive Index | 1.557-1.559 |
| Solubility | Soluble in organic solvents such as ethanol, ether, and benzene; slightly soluble in water |
| Chemical Structure | Contains an aromatic ring with a chlorine atom, an ethylamine side chain, and an amino group |
| Uses | Used as an intermediate in the synthesis of pharmaceuticals, dyes, and other organic compounds. It is also employed in the preparation of chiral ligands and catalysts in asymmetric catalysis. |
| Synthesis Methods | Prepared by the reduction of 4-chlorophenacetaldehyde with ammonia or its derivatives, or by the catalytic hydrogenation of 4-chlorophenacetonitrile. |
| Health Effects | May cause irritation to skin, eyes, and respiratory tract. Ingestion and inhalation may be harmful. |
| Environmental Considerations | Handle and dispose of 4-Chlorophenethylamine according to local environmental regulations. |
| Safety Precautions | Wear appropriate protective clothing, gloves, and eye protection. Store in a cool, dry place, away from heat, sparks, and open flames. Keep away from oxidizing agents and incompatible materials. |
