4-Chloro-2-nitrotoluene
Pharmaceutical Materials 2025-03-02
Production method It is obtained from p-nitrotoluene by chlorination. First to the acid-resistant ceramic three bottles to add dry pure p-nitrotoluene, external water bath heating to 55 ° C, and then add a small amount of iodine and iron filings, at 50-60 ° C into the chlorine, a few hours, chlorine absorption up to the theoretical amount of stop. At this time there are reactants precipitated in the bottle, through the steam heating so that the reactants melted and withdrawn, washed with 5% dilute hydrochloric acid twice. Then wash with 1% sodium carbonate solution once, and finally wash with hot water once, the oil will be stirred into the cold water, that is, into the granular material, filtration, washed with cold water, blow-drying at 40 ℃ that is the finished product. Industrial production, the operation process can be carried out in a dry reaction pot, the molten nitrotoluene into the reaction pot to add iron wire and iodine tablets (or add ferric chloride), at 58-62 ℃ into the equimolar amount of chlorine, washed with hot water, sodium carbonate and neutralization, poured into ice water, stirring to precipitate crystals, filtration, drying that is, the finished product.
| Chemical Formula | C₇H₆ClNO₂ |
| Molecular Weight | 171.58 g/mol |
| Appearance | Needle-like crystals or yellow to light brown solid |
| Density | 1.2559 g/mL at 80/4°C or 1.3±0.1 g/cm³ |
| Melting Point | 35-38°C |
| Boiling Point | 239-240°C at 718 mmHg or 238.5±20.0°C at 760 mmHg |
| Flash Point | 98.1±21.8°C or 110°C |
| Refractive Index | 1.5413 or 1.570 |
| Solubility | Soluble in hot ethanol and ether, insoluble in water (109 mg/L at 20°C) |
| Applications | Intermediate in the production of ice dyes, such as Red Base KB and Naphthol AS-KB |
| Safety Information | Irritating; wear protective gloves, goggles, and clothing; avoid inhaling vapors, aerosols, or gases; classified as flammable liquid (Category 4), skin corrosive (Category 1B), and causing serious eye damage (Category 1) under GHS |
| Regulatory Status | CAS No.: 89-59-8; EINECS No.: 201-921-2; Hazardous goods transport code: UN 3457 6.1/PG 3; WGK Germany: 2; Customs code: 2904909090 |
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