4-Bromomethyl-1,2-dihydroquinoline-2-one
Pharmaceutical Materials 2025-03-02
CAS Number: 4876-10-2
Molecular Formula: C10H8BrNO
Molecular Weight: 238.08 g/mol
Appearance: Solid (often described as a white or off-white powder)
Melting Point: 255-258°C
Usage: Used as a pharmaceutical intermediate.
Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
| Attribute | Information |
|---|---|
| Chemical Name | 4-Bromomethyl-1.2-dihydroquinoline-2-one |
| CAS Number | 4876-10-2 |
| Synonyms | 4-Bromomethylquinolin-2(1H)-one; 4-(Bromomethyl)-2-quinolinol; 4-(Bromomethyl)-1.2-dihydroquinolin-2-one; Bromomethylquinolin-2-one; BMQ |
| Molecular Formula | C10H8BrNO |
| Molecular Weight | 238.08 g/mol |
| Appearance | Off-white to white powder |
| Melting Point | 255-258 °C |
| Boiling Point | 391.8 °C (at 760 mmHg) |
| Density | 1.542 g/cm³ |
| Flash Point | 190.8 °C |
| Refractive Index | 1.616 |
| Solubility | Soluble in organic solvents |
| Chemical Structure | Quinoline ring with a bromomethyl group at the 4-position and a keto group at the 2-position |
| Applications | Primarily used as an intermediate in the synthesis of pharmaceuticals, specifically in the production of Rebamipide. |
| Synthesis Route | Typically synthesized through condensation reactions involving quinoline derivatives and brominating agents. |
| Safety Precautions | May cause irritation to skin, eyes, and respiratory tract. Handle with appropriate personal protective equipment. Store in a cool, dry place, away from incompatible materials and direct sunlight. |
| Environmental Considerations | Dispose of according to local regulations for hazardous waste. |
