4-Bromobenzoyl chloride
Chemical Additives 2025-03-18
4-Bromobenzoyl Chloride
Chemical Formula: C₇H₄BrClO
Structure: Acyl chloride derivative of 4-bromobenzoic acid, with:
- A bromine atom (-Br) at the 4-position of the benzene ring.
- A carbonyl chloride group (-COCl) at the 1-position.
Physical Properties
- Appearance: Clear, colorless to pale yellow liquid.
- Odor: Pungent.
- Reactivity:
- Moisture-sensitive: Reacts violently with water, releasing HCl.
- Highly reactive in acylation reactions (e.g., Friedel-Crafts, nucleophilic substitutions).
Applications
- Organic Synthesis:
- Reagent for introducing 4-bromobenzoyl groups into molecules.
- Synthesis of pharmaceuticals (e.g., kinase inhibitors) and agrochemicals.
- Biomolecule Modification:
- Acylation of peptides/proteins for functionalization.
- Industrial Chemistry:
- Production of dyes (e.g., azo dyes) and polymers (e.g., polyamides).
Safety Considerations ⚠️
- Health Hazards:
- Corrosive: Causes severe burns to skin, eyes, and respiratory tract.
- Releases HCl gas upon hydrolysis.
- Handling:
- Use PPE (gloves, goggles, respirator) and work in a fume hood.
- Storage:
- Store in a cool, dry, airtight container away from moisture and incompatible substances (e.g., bases, alcohols).
Summary:
4-Bromobenzoyl chloride’s high reactivity and acyl chloride functionality make it indispensable in drug discovery, agrochemicals, and polymer chemistry. Strict safety protocols are critical due to its corrosive nature and moisture sensitivity.
