Pharmaceutical Materials

4-Bromo-2-fluorobenzonitrile is a crucial organic compound characterized by its bromine and fluorine substituents on a benzene ring with a nitrile functional group. It serves as a key intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals due to its reactivity and structural versatility. Its bromine and fluorine atoms enable selective functionalization reactions, while the nitrile group facilitates nucleophilic additions and reductions. The compound typically appears as a crystalline powder or chunks, with a melting point ranging from 69-72°C and a boiling point of 238-239°C. Its insolubility in water and moderate density (1.7286 g/cm³) make it suitable for various organic transformations. In industrial applications, it is used as a building block for complex molecules, leveraging its ability to undergo aromatic substitution and C–C bond-forming reactions.

Usage： Used as pharmaceutical intermediate and other organic synthetic intermediates.

Packaging and Shipping： 25KG/drum.

Storage: Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.

 

Name	4-Bromo-2-fluorobenzoic Acid
Synonyms	4-Bromo-2-fluorobenzoic Enzalutamide Impurity 13 4-Bromo-2-fluorobenzoic Acid 4 – broMine – 2 – fluoro benzoic acid
CAS	112704-79-7
EINECS	630-232-3
InChI	InChI=1/C7H7BrFN/c8-6-2-1-5(4-10)7(9)3-6/h1-3H,4,10H2

Molecular Formula	C7H4BrFO2
Molar Mass	219.01
Density	1.571g/cm3
Melting Point	208-213℃
Boling Point	244.5°C at 760 mmHg
Flash Point	101.7°C
Vapor Presure	0.0302mmHg at 25°C
Appearance	White powder
Storage Condition	Room Temprature
Refractive Index	1.566
Use	Application 4-bromo-2-fluorobenzoic acid is an organic intermediate, which can be prepared from 2-fluoro-4-bromotoluene by oxidation reaction. It has been reported in the literature to be usefl for the preparation of enzalutamide intermediates and Venetoclax key intermediates.

,Disclaimer: The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.

If you're ready to take the next step, Leave your message below and we’ll reply soon. 20+ years of chemical manufacturing & export experience, a partner you can trust.