4-Aminopyrazolo[3,4-d]pyrimidine
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Category：Pharmaceutical Materials Own Brand：MT /MOQ:100KG /From China/ B2B only.
Introduction
CAS Number: 2380-63-4
Molecular Formula: C5H5N5
Molecular Weight: 135.13 g/mol
Appearance: Cream-colored or mixture of beige and white powder
Density: 1.612 g/cm³
Boiling Point: 431.09 °C
Flash Point: 244.38 °C
Usage: It is used as an organic synthesis intermediate.
| Property/Characteristic | Details |
|---|---|
| Chemical Name | 4-Aminopyrazolo[3.4-d]pyrimidine |
| CAS Number | 2380-63-4 |
| Molecular Formula | C5H5N5 |
| Molecular Weight | 135.13 g/mol |
| Appearance | Milky white powder |
| Density | 1.612 g/cm³ |
| Melting Point | >325 °C (lit.) |
| Boiling Point | 431.1ºC at 760 mmHg |
| Flash Point | 244.4ºC |
| Solubility | Insoluble in water |
| Hazard Classification | Acute toxicity, oral (Category 3); Skin irritation (Category 2); Eye irritation (Category 2A); Specific target organ system toxicity (single exposure) (Category 3) |
| Primary Hazards | Skin irritation, eye irritation, respiratory irritation |
| Safety Precautions | Avoid inhalation, do not eat, drink, or smoke while handling. Wear protective gloves, eye protection, and face shield. In case of skin or eye contact, wash immediately with plenty of water and seek medical attention if necessary. |
| Applications | As an intermediate in organic synthesis, particularly in the pharmaceutical industry. It has shown anticancer activity and is a potent inhibitor of RET (rearranged during transfection) lung cancer oncogene. |
| Additional Notes | It can inhibit various protein kinases such as BTK, CDK1/2. Src kinase, and RIPK1 in vitro. It is also known by its aliases such as 4-Aminopyrazolo[3.4-d]pyrimidine, 4-Aminopyrazolo[3.4-d] pyrimidin-4-amine, and Pyrazoloadenine. |
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