4-Amino-2,6-dichlorophenol
Agrochemicals 2025-03-02
4-Amino-2,6-dichlorophenol (CAS No. 527-62-8)
1. Basic Information
- IUPAC Name: 4-Amino-2,6-dichlorophenol
- Synonyms:
- 2,6-Dichloro-4-hydroxyaniline
- ADCP
- CAS Number: 527-62-8
- Molecular Formula: C₆H₅Cl₂NO
- Molecular Weight: 178.02 g/mol
- Appearance: Light brown to gray crystalline powder
- Odor: Slight phenolic odor
2. Physical and Chemical Properties
| Property | Value |
|---|---|
| Melting Point | 168–172°C (334–342°F) |
| Solubility | – Water: Slightly soluble (0.5 g/L at 20°C) |
| – Organic solvents: Soluble in ethanol, acetone, DMSO | |
| pKa | ~5.2 (phenolic OH) |
| Log Pow | 2.1 (octanol/water) |
| Vapor Pressure | <0.1 mPa at 25°C |
3. Chemical Structure
Cl
|
HO-◯-NH₂
|
Cl
(◯ = benzene ring with substitutions at positions 1, 2, 4, and 6)
4. Hazards (GHS Classification)
- Health Hazards:
- Harmful if swallowed (H302)
- Causes skin irritation (H315)
- Causes serious eye damage (H318)
- Environmental:
- Toxic to aquatic life (H411)
- NFPA Rating: Health 2, Flammability 1, Reactivity 0
5. Storage and Handling
- Storage:
- Keep in tightly sealed amber containers
- Store in a cool, dry, well-ventilated area
- Handling:
- Use nitrile gloves, safety goggles, and fume hood
- Avoid dust formation
6. Applications
- Dye Intermediate:
- Synthesis of azo dyes and pigments
- Pharmaceuticals:
- Building block for antimicrobial agents
- Agrochemicals:
- Precursor for herbicide synthesis
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