4-Amino-2-fluorobenzamide CAS No.:609783-45-1
Pharmaceutical Materials 2025-03-03
4-Amino-2-fluorobenzamide is a pivotal intermediate in organic synthesis, extensively utilized in pharmaceuticals, agrochemicals, and materials science. Its structure features an amino group and a fluorine atom on a benzamide backbone, enabling selective functionalization through nucleophilic substitution and metal-catalyzed coupling reactions. This compound serves as a precursor for fluorinated pharmaceuticals, including antiviral and anticancer agents, where the trifluoromethyl-like electronic properties of fluorine enhance bioavailability and metabolic stability. Industrial synthesis routes typically involve amide formation from 4-amino-2-fluorobenzoic acid or fluorination of 4-aminobenzamide derivatives. Its high purity (≥98%) and stability make it indispensable in pharmaceutical R&D, particularly in drug design targeting specific biological pathways. Due to its moisture sensitivity, it requires storage under inert conditions.
Usage： Used as pharmaceutical intermediate and intermediate of synthetic materials.
Packaging and Shipping： 25KG/drum.
Storage: Keep container sealed and store in an ventilated, low temperature, dry warehouse, separate from foods and oxidizing agents.
| Name | 4-Amino-2-fluorobenzamide |
| Synonyms | Enzalutamide Impurity 23 4-Amino-2-fluorobenzamide BENZAMIDE, 4-AMINO-2-FLUORO- Benzamide, 4-amino-2-fluoro- (9CI) |
| CAS | 609783-45-1 |
| Molecular Formula | C7H7FN2O |
| Molar Mass | 154.14 |
| Density | 1.344±0.06 g/cm3(Predicted) |
| Boling Point | 299.6±30.0 °C(Predicted) |
| pKa | 16.09±0.50(Predicted) |
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