3,5-Difluorochlorobenzene CAS No.:1435-43-4
Pharmaceutical Materials 2025-03-02
3,5-Difluorochlorobenzene (3,5-DFCB) is a crucial intermediate in organic synthesis, widely utilized in pharmaceuticals, agrochemicals, and specialty chemicals. Its molecular structure features a chlorine atom and two fluorine atoms on a benzene ring, offering unique reactivity for fluorination and cross-coupling reactions. 3,5-DFCB serves as a precursor for drugs (e.g., antidepressants, kinase inhibitors) and pesticides, enabling the introduction of fluorine functional groups that enhance metabolic stability and bioavailability. Synthetic routes include halogenation of substituted benzene derivatives or fluorination of chlorobenzene intermediates. Its high demand stems from its versatility in forming C–N, C–O, and C–C bonds, making it indispensable in modern chemical manufacturing.
Usage： Used as pharmaceutical intermediate and other organic synthetic intermediates.
Packaging and Shipping： 25kg/ drum or as per buyer requirement.
Storage: Ventilated and dry; separate from alkalis, oxidisers, organic materials and flammable materials.
| Name | 3,5-Difluorochlorobenzene |
| CAS No. | 1435-43-4 |
| Molecular Formula | C₆H₃ClF₂ |
| Molecular Weight | 148.54 g/mol |
| Appearance | Colorless to almost colorless liquid |
| Purity | ≥99% (GC verified) |
| Applications | Pharmaceutical intermediates, agrochemical synthesis, liquid crystal materials |
| Synthesis | Bromination of 6-chloro-2,4-difluoroaniline with NaNO₂/NaH₂PO₂, yield ≥97% |
| QC Standards | Purity ≥99%, residual solvents <0.5%, heavy metals <10 ppm |
| Storage | Sealed, cool (room temperature), dry conditions |
| Packaging | 1g, 5g, 25g, 1kg (customizable) |
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