Pharmaceutical Materials

It is used as an important intermediate of sulfonamide synergist and antibacterial synergist TMP.

Product Name

3.4.5-Trimethoxybenzaldehyde

Multiple Names

3.4.5-Trimethoxybenzaldehyde;

Benzaldehyde,

3.4.5-Trimethoxy-;

4-08-00-02719 (Beilstein Handbook Reference);

AI3-36673;

BENZALDEHYDE,3.4.5-TRIMETHOXY-;

BRN 0395163;

NSC 16692; TMBA

CAS No. 86-81-7

EC No. 201-701-6

MF No. C10H12O4

MW No. 196.1999

Advantage of 3.4.5-Trimethoxybenzaldehyde CAS No. 86-81-7

Good intermediate

Wildly usage application

Names and Identifiers

Name	3,4,5-Trimethoxybenzaldehyde
Synonyms	TMBA NSC 16692 AI3-36673 BRN 0395163 OTAVA-BB BB7018801952 Trimetazidine Impurity 9 3,4,5-Trimethoxybenzaldeh 3,4,5-methoxybenzaldehyde 3,4,5-tiMethoxybenzaldehyde 3,4,5-Trimethoxybenzaldehyde 3,4,5-TriMethoxybenzaldenyde 3,4,5-TrimethoxybenZHldehyde BENZALDEHYDE,3,4,5-TRIMETHOXY- Benzaldehyde, 3,4,5-trimethoxy- Three, four, five – preparation benzaldehyde 4-08-00-02719 (Beilstein Handbook Reference)
CAS	86-81-7
EINECS	201-701-6
InChI	InChI=1/C10H12O4/c1-12-8-4-7(6-11)5-9(13-2)10(8)14-3/h4-6H,1-3H3
InChIKey	OPHQOIGEOHXOGX-UHFFFAOYSA-N

​Physico-chemical Properties

Molecular Formula	C10H12O4
Molar Mass	196.2
Density	1.2166 (rough estimate)
Melting Point	72-74 °C (lit.)
Boling Point	163-165 °C/10 mmHg (lit.)
Flash Point	163-165°C/10mm
Water Solubility	slightly soluble
Solubility	slightly soluble
Vapor Presure	0.000565mmHg at 25°C
Appearance	White crystal
Color	White to creamy
BRN	395163
Storage Condition	Keep in dark place,Sealed in dry,Room Temperature
Sensitive	Air Sensitive
Refractive Index	1.5550 (estimate)
MDL	MFCD00003364
Physical and Chemical Properties	White to yellowish needle-like crystals. melting point 74-75 ℃
Use	Trimethoprim for synthesis of antimicrobial Potentiator

Risk and Safety

Risk Codes	R36/37/38 – Irritating to eyes, respiratory system and skin. R34 – Causes burns
Safety Description	S22 – Do not breathe dust. S24/25 – Avoid contact with skin and eyes. S45 – In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/37/39 – Wear suitable protective clothing, gloves and eye/face protection. S27 – Take off immediately all contaminated clothing. S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
UN IDs	UN2811
WGK Germany	3
RTECS	CU8462000
TSCA	Yes
HS Code	29124900
Hazard Note	Irritant

Reference Information

trait	white to yellowish needle-like crystals.
Use	for synthesis of antibacterial synergist trimethoprim for synthesis of antibacterial synergist trimethoprim for use as sulfanilamide synergist, an important intermediate of the antibacterial synergist TMP.
production method	1. From gallic acid (or tannic acid) by dimethyl sulfate methylation, esterification, and then hydrazine hydrate hydrazine reaction, and then the red blood salt oxidation system. The yield of industrial production was more than 70%. 2. From vanillin aldehyde by bromination, hydrolysis, methylation and derived. With p-nitrotoluene as raw material, by oxidation-reduction, then with sodium nitrite diazotization, hydrolysis of p-hydroxybenzaldehyde, bromination, dimethoxylation, methylation and derived. Further, 3,4, 5-trimethoxybenzaldehyde can also be prepared from trimethoxybenzonitrile and p-hydroxybenzaldehyde.

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