Pharmaceutical Materials

3,3-Tetramethyleneglutarimide, also known as 8-azaspiro[4.5]decane-7,9-dione, is a cyclic imide derivative with the molecular formula C₉H₁₃NO₂. It serves as a crucial intermediate in pharmaceutical synthesis, particularly in the production of anti-anxiety medications such as buspirone (Buspar®). Structurally characterized by a tetramethylene bridge and a formylimide functionality, it exhibits high reactivity and stability under ambient conditions. Its synthesis typically involves cyclocondensation reactions using 1,1-cyclopentanedicarboxylic acid and urea, yielding a white crystalline powder with a melting point of 153–155 °C. Beyond pharmaceuticals, it finds applications in organic synthesis and as a reagent in life science research, underscoring its versatility in chemical and biochemical domains.

Usage：Used as a commonly pharmaceutical intermediate for the preparation of some drugs. At present, it is mostly used for the preparation of antianxiety drug buspironone hydrochloride, and it is the key intermediate for the preparation of this kind of drugs.

Packaging and Shipping： 25KG/drum or as per buyer requirements.

Storage: Keep the container airtight and store in a cool, ventilated warehouse.Stay away from incompatible materials such as oxidants.

Name	3,3-Tetramethyleneglutarimide (3,3-四亚甲基戊二酰亚胺)
CAS No.	1075-89-4
Molecular Formula	C₉H₁₃NO₂
Molecular Weight	167.21 g/mol
Appearance	White to off-white crystalline powder
Melting Point	153-155°C
Boiling Point	350.7°C at 760 mmHg
Solubility	Slightly soluble in chloroform and methanol
Synthesis	Prepared by reacting 1,1-cyclopentanediacetic acid with urea, followed by recrystallization with ethanol and activated carbon; yield: 80.1-89.5%
Applications	Key intermediate for the synthesis of anti-anxiety drug buspirone hydrochloride; versatile building block in organic synthesis
Safety	Toxic if swallowed; harmful to aquatic life with long-lasting effects; store in a sealed container in a cool, dry place; UN 2811 6.1 / PGIII, Hazard Class 6.1

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