3,3-Dimethyl-2-oxobutyric acid
Agrochemicals 2025-03-02
3,3-Dimethyl-2-oxobutyric Acid
Chemical Name: 3,3-Dimethyl-2-oxobutyric acid
Synonyms: α-Ketoisovaleric acid; 3-Methyl-2-oxobutanoic acid (Note: Verify exact isomer)
CAS Number: 759-05-7
Molecular Formula: C₆H₁₀O₃
Molecular Weight: 130.14 g/mol
Physical & Chemical Properties
| Property | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Melting Point | 37-40°C (98-104°F) |
| Boiling Point | Decomposes (~200°C) |
| Density | ~1.12 g/cm³ (estimated) |
| Solubility | Soluble in water, ethanol, ether |
| pKa | ~2.5 (carboxyl group) |
| Refractive Index | 1.439 (20°C, for liquid form) |
Hazard & Safety Information (GHS)
Warning Symbols:
⚠️ Skin/Eye Irritant (Category 2)
Hazard Codes:
• H315: Causes skin irritation
• H319: Causes serious eye irritation
Precautionary Measures:
• P264: Wash hands after handling
• P280: Wear gloves/eye protection
• P305+P351+P338: IF IN EYES: Rinse cautiously
Chemical Behavior
• Reactivity:
- Decarboxylates at high temperatures
- Forms enolates with bases
- Reacts with nucleophiles (e.g., amines) to form Schiff bases
• Stability: - Hygroscopic (absorbs moisture)
- Store under inert atmosphere
Applications
✔ Biochemical Research:
- Intermediate in valine metabolism (ketoacid)
- Precursor for branched-chain amino acid studies
✔ Organic Synthesis: - Chiral building block
- Pharmaceutical intermediates
Disclaimer:
The above content is for reference and communication only among industry insiders, and does not guarantee its accuracy or completeness. According to relevant laws and regulations and the regulations of this website, units or individuals who purchase related items should obtain valid qualifications and qualification conditions.
