Agrochemicals

3-Pyridinecarboxaldehyde (CAS No. 500-22-1) 

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1. Basic Information

• IUPAC Name: Pyridine-3-carbaldehyde
• Synonyms:
  • Nicotinaldehyde
  • 3-Formylpyridine
• CAS Number: 500-22-1
• Molecular Formula: C₆H₅NO
• Molecular Weight: 107.11 g/mol
• Appearance: Colorless to pale yellow liquid
• Odor: Pungent, pyridine-like odor

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2. Physical and Chemical Properties

Property	Value
Boiling Point	85–87°C (185–189°F) at 15 mmHg
Density	1.13 g/cm³ (20°C)
Refractive Index	1.550–1.552 (20°C)
Flash Point	72°C (162°F) (closed cup)
Solubility	– Water: Partially soluble
	– Organic solvents: Miscible with ethanol, ether, acetone
Vapor Pressure	0.3 mmHg at 25°C

 

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3. Hazards (GHS Classification)

• Health Hazards:
  • Harmful if swallowed (H302)
  • Causes skin irritation (H315)
  • Causes serious eye irritation (H319)
• Environmental: Toxic to aquatic life (H411)
• NFPA Rating: Health 2, Flammability 2, Reactivity 1

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4. Storage and Handling

• Storage:
  • Keep in tightly sealed amber containers under nitrogen
  • Store in a cool, dry, well-ventilated area
• Handling:
  • Use nitrile gloves, safety goggles, and a fume hood
  • Avoid contact with strong oxidizers

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5. Applications

• Pharmaceuticals:
  • Intermediate for antihypertensive drugs (e.g., nifedipine)
• Agrochemicals:
  • Building block for pesticides
• Organic Synthesis:
  • Precursor for Schiff bases and heterocycles

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