3-Methylsalicylic acid
Pharmaceutical Materials 2025-03-02
CAS Number: 83-40-9
Molecular Formula: C8H8O3
Molecular Weight: 152.15 g/mol
Appearance: White to slightly red crystalline solid Melting Point: 163-165°C Usage: Used as an intermediate in organic synthesis and dye manufacturing.
Names and Identifiers
| Name | 3-Methylsalicylic acid |
| Synonyms | 3-MS Cresotic acid o-Cresotic acid o-Kresotinic Acid 3-Methylsalicylic ac 2-methylsalicylicacid 3-Methylsalicylic acid 3-Methylsalycilic acid 2-hydroxy-m-toluic acid 2-hydroxy-3-methylbenzoate 2-hydroxy-3-methyl-benzoicaci Acido 3-ossi-5-metil-benzoico 2-Hydroxy-3-methylbenzoic acid 2-Hydroxy-3-methyl benzoic acid |
| CAS | 83-40-9 |
| EINECS | 201-473-8 |
| InChI | InChI=1/C8H8O3/c1-5-3-2-4-6(7(5)9)8(10)11/h2-4,9H,1H3,(H,10,11)/p-1 |
| InChIKey | WHSXTWFYRGOBGO-UHFFFAOYSA-N |
83-40-9 – Physico-chemical Properties
| Molecular Formula | C8H8O3 |
| Molar Mass | 152.15 |
| Density | 1.2143 (rough estimate) |
| Melting Point | 163-165 °C (lit.) |
| Boling Point | 234.6°C (rough estimate) |
| Flash Point | 145.4°C |
| Water Solubility | 1.5 g/L (20 ºC) |
| Solubility | methanol: soluble5%, clear to slightly hazy (colorlessto faint brown) |
| Vapor Presure | 0.065-0.307Pa at 25℃ |
| Appearance | Fine Powder |
| Color | Almost white |
| Merck | 14,2581 |
| BRN | 2086811 |
| pKa | pK1:2.99 (25°C) |
| PH | 2.8 (1.5g/l, H2O, 20℃) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Refractive Index | 1.4945 (estimate) |
| MDL | MFCD00002448 |
| Physical and Chemical Properties | Melting point 164-167°C water-soluble 1.5g/L (20°C) |
| Use | Useful as intermediates in organic synthesis and dyes |
83-40-9 – Risk and Safety
| Hazard Symbols | Xn – Harmful |
| Risk Codes | R22 – Harmful if swallowed R37/38 – Irritating to respiratory system and skin. R41 – Risk of serious damage to eyes |
| Safety Description | S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/39 – S22 – Do not breathe dust. |
| UN IDs | UN 2811 |
| WGK Germany | 3 |
| RTECS | BZ4385000 |
| TSCA | Yes |
| HS Code | 29182990 |
| Toxicity | LD50 oral in rat: 445mg/kg |
Reference Information
| LogP | 2.79-2.86 |
| biological activity | 3-methylsalicylacid is a salicylic acid derivative that acts on human plasma by activating the fibrinolytic system, and has a significant fibrinolytic activity. |
| Use | This product can be used in the manufacture of azo dyes, especially acid medium bleaching blue B Dye, it can be used as raw material to prepare blue, purple, brown, Green and other triphenylmethane dye more than 20 kinds of media. used as intermediate in organic synthesis and dyes |
| production method | It is produced by solid phase method and solvent method, the latter does not require the treatment of a dry powder of the highly hygroscopic sodium salt of O-cresol. The reaction material is a liquid phase carbon carboxylation reaction, CO2 is completed once, without the need for semi-vapor phenol, can be produced in the ordinary pressure equipment, reducing the use of dehydration and carbon carboxylation equipment. The principle of production is the same for both methods. |
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