Chemical Intermediates

CAS: 877-22-5

Appearance: Pale yellow crystalline powder

Purity: ≥98% Capacity: 200mt/year

MOQ: 100g Application: organic intermediate

Standard: Enterprise export

Manufacturer: Jinan Finer Chemical Co., Ltd

Synonyms: 2-Hydroxy-3-methoxybenzoic acid

Molecular Formula: C8H8O4

Molecular Weight: 168.15 CAS

Registry Number: 877-22-5

Melting point: 147-152 ºC

Names and Identifiers

Name	2-Hydroxy-3-Methoxy Benzoic Acid
Synonyms	3-Methoxysalicylic a acideorthovanillique 2-hydroxy-m-anisicaci 3-hydroxy-m-anisicacid 3-METHOXYSALICYLIC ACID GUAIACOL-3-CARBOXYLIC ACID 2-hydroxy-3-methoxy-benzoicaci 3-METHOXY-2-HYDROXYBENZOIC ACID 2-Hydroxy-3-methoxybenzoic acid 2-Hydroxy-3-Methoxy Benzoic Acid Benzoic acid,2-hydroxy-3-Methoxy- 3-METHOXYSALICYLIC ACID MONOHYDRATE Guaiacol-3-carboxylic Acid2-Hydroxy-3-methoxybenzoic Acido-Vanillic Acid
CAS	877-22-5
EINECS	212-888-9
InChI	InChI=1/C8H8O4/c1-12-6-4-2-3-5(7(6)9)8(10)11/h2-4,9H,1H3,(H,10,11)

877-22-5 – Physico-chemical Properties

Molecular Formula	C8H8O4
Molar Mass	168.15
Density	1.1816 (rough estimate)
Melting Point	147-150°C(lit.)
Boling Point	217.07°C (rough estimate)
Flash Point	131.7°C
Solubility	DMSO (Slightly), Methanol (Slightly)
Vapor Presure	0.000182mmHg at 25°C
Appearance	Light brown powder
Color	Off-White to Beige
BRN	2209642
pKa	2.85±0.10(Predicted)
Storage Condition	Sealed in dry,Room Temperature
Refractive Index	1.4611 (estimate)
MDL	MFCD00002445

877-22-5 – Risk and Safety

Risk Codes	R36/37/38 – Irritating to eyes, respiratory system and skin. R20/21/22 – Harmful by inhalation, in contact with skin and if swallowed.
Safety Description	S26 – In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 – Wear suitable gloves and eye/face protection S36 – Wear suitable protective clothing.
WGK Germany	3
RTECS	BZ4840000
HS Code	29189900

877-22-5 – Introduction

2-Hydroxy-3-Methoxy Benzoic Acid, also known as 2-Hydroxy-3-Methoxy Benzoic Acid, the chemical formula is C8H8O4. The following is a description of the properties, uses, preparation and safety information of the compound:

Nature:
-Appearance: White or almost white crystal
-melting point: 173-177 ℃
-Solubility: Soluble in ethanol, chloroform, ether and acetic acid, slightly soluble in water

Use:
-Pharmaceutical field: 2-Hydroxy-3-Methoxy Benzoic Acid can be used as an intermediate for antibacterial agents, antioxidants and whitening agents.
-cosmetics field: commonly used in sunscreen, skin care products and whitening products.
-Laboratory research: It is widely used in chemical synthesis and organic synthesis as an intermediate.

Preparation Method:
2-Hydroxy-3-Methoxy Benzoic Acid can be obtained by methylation of p-hydroxybenzoic acid. The specific preparation method is as follows:
1. Hydroxybenzoic acid is reacted with methanol under acidic conditions.
2. After esterification reaction, 2-Hydroxy-3-Methoxy Benzoic Acid methyl ester is generated.
3. Hydrolyze the 2-Hydroxy-3-Methoxy Benzoic Acid methyl ester to generate 2-Hydroxy-3-Methoxy Benzoic Acid.

Safety Information:
2-Hydroxy-3-Methoxy Benzoic Acid has no obvious toxicity or danger under normal conditions of use. However, as with any chemical, proper laboratory practices and safety measures should be followed to avoid skin and eye contact and to avoid inhalation of dust or gases. If necessary, wear appropriate personal protective equipment and properly store and handle the compound.

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